Made up of St. Croix, St. John and St. Thomas, the laidback USVI offer sophisticated dining, turquoise waters and quaint towns. On St. Croix, Christiansted's colorful Danish Colonial buildings provide a lovely backdrop for dining or sailing. Underwater coral gardens are heaven for divers. On St. Thomas, shopping mecca Charlotte Amalie has hopping nightlife. Tranquil St. John offers quiet trails, secluded coves and lively Cruz Bay's shops and bars. Ferries and local air services link the islands.

Like all of the U.S. Virgin Islands, St. Thomas has plenty of opportunities to lounge on the beach, splash in the sea, or amp it up with watersports. It also boasts a bountiful duty-free shopping scene – just be prepared to brave the cruise ship crowds. Charlotte Amalie swells with Danish colonial architecture and pirate legend. Shiver ye timbers at Blackbeard’s Castle, then work up an appetite by climbing the historic 99 Steps, constructed from the ballast bricks of 18th century Danish ships.

Ecotourism is alive and kicking on St. John. There's more than enough to do on land, from watching for wildlife in the national park to hiking miles of trails or strolling sandy white beaches. Hit the water for amazing snorkeling, swimming, even underwater photography—of course. This is the Caribbean, after all.

The glowing Mosquito Bay is a vision of bizarre beauty. Thanks to a bioluminescent microorganism, the water is a cool electric blue, looking somewhat like a fantastical sci-fi lagoon. Kayak or hop into a clear-bottomed pontoon boat to glide along the neon waters. Swimmers and snorkelers will adore the pristine, undeveloped beaches. Keep an eye out for the playful feral horses that gallop along the dunes, or visit the stately ceiba tree that’s been keeping watch over the highland for three centuries.

Sailing, diving, fishing and soaking up the sun on perfect beaches is what it's all about on the 60 idyllic British Virgin Islands. Largest island Tortola, home to capital Road Town, is a 12 by three mile haven of white sand, lush green mountains, ruins and rum distilleries. Underwater caverns beckon from dramatic Virgin Gorda. Island time rules on laid-back Jost Van Dyke, where swim-up bars serve delicious rum concoctions. Pristine beaches lure visitors to beautiful coral island Anegada.

Life is just a little bit slower on Virgin Gorda, so named because this British Virgin Island resembles a large reclining woman. The laid-back pace of the island is the perfect excuse to take your time, whether you’re wading along the granite grottoes of The Baths, doing some casual snorkeling in Devil’s Bay, or exploring the stone ruins of a 19th century Copper Mine. Hanging out in the hammock at Mad Dog while you sip a Painkiller is the ultimate in Virgin Gorda relaxation.

The festive city of San Juan is the perfect place to experience true Puerto Rican culture. Get to know its roots by exploring the vibrant neighborhood of El Viejo San Juan (Old San Juan), which consists mostly of Spanish colonial buildings. Flesh out your self-guided history lesson with a visit to El Castillo San Felipe del Morro, a 16th century citadel that’s a UNESCO World Heritage Site. Then reward yourself with a cooling dip at Luquillo or Carolina Beach, then a tasty tour of the Bacardi rum plant.

Conquering New York in one visit is impossible. Instead, hit the must-sees – the Empire State Building, the Statue of Liberty, Central Park, the Metropolitan Museum of Art – and then explore off the beaten path with visits to The Cloisters or one of the city’s libraries. Indulge in the bohemian shops of the West Village or the fine dining of the Upper West Side. The bustling marketplace inside of Grand Central Station gives you a literal taste of the best the city has to offer.

Walk the Freedom Trail the first time you visit Boston and you'll quickly get a sense of this coastal city's revolutionary spirit and history. But make sure you also explore some of Boston's fine museums (try the Isabella Stewart Gardner, featuring masterpieces displayed in their collector's mansion) and old neighborhoods (like the North End, Boston's Little Italy). You can't claim to have experienced real Boston culture, though, until you've watched a Red Sox game from the bleachers.

The windy city is a cornucopia of modern art, fine dining, cutting edge comedy, and die-hard sports fans. Snap a photo of your reflection in the silver Cloud Gate sculpture at Millennium Park before heading to Grant Park to get hit with the refreshing spray of Buckingham Fountain. There are dozens of museums and theater companies in Chicago, so a cultural experience is never hard to find. You’re sure to laugh your head off at the Second City Theater, the professional launch pad of many famous comedians.

Whether you’re a high roller or a low-key lounger, Las Vegas has something to suit your vacation taste. Sample fare from top chefs and cornucopian buffets, try your luck at one of the world’s premier casinos, or take in a spectacular show. Just wandering the Strip is enough to get your heart pumping. Once you’ve had enough of the razzle-dazzle, wave hello to the toothy sea life at the Mandalay Bay Shark Reef, hike Red Rock Canyon, or visit the Neon Museum, where old signs take on new life.

Barcelona feels a bit surreal – appropriate, since Salvador Dali spent time here and Spanish Catalan architect Antoni Gaudí designed several of the city’s buildings. Stepping into Gaudí’s Church of the Sacred Family is a bit like falling through the looking glass - a journey that you can continue with a visit to Park Güell. Sip sangria at a sidewalk café in Las Ramblas while watching flamboyant street performers, then create your own moveable feast by floating from tapas bar to tapas bar.

From Shoreditch’s swaggering style to Camden’s punky vibe and chic Portobello Road, London is many worlds in one. The city’s energy means that no two days are the same. Explore royal or historic sites, tick off landmarks from your bucket list, eat and drink in exclusive Michelin-starred restaurants, enjoy a pint in a traditional pub, or get lost down winding cobbled streets and see what you stumble across – when it comes to London, the possibilities are endless.

Lingering over pain au chocolat in a sidewalk café, relaxing after a day of strolling along the Seine and marveling at icons like the Eiffel Tower and the Arc de Triomphe… the perfect Paris experience combines leisure and liveliness with enough time to savor both an exquisite meal and exhibits at the Louvre. Awaken your spirit at Notre Dame, bargain hunt at the Marché aux Puces de Montreuil or for goodies at the Marché Biologique Raspail, then cap it all off with a risqué show at the Moulin Rouge.

This city, full of colorful homes, canals and bridges, is one of Europe's most picturesque capitals. Must-sees on any visitor's itinerary include the Anne Frank House, the Van Gogh Museum and the world's only floating flower market. Rent a bike and join thousands of locals navigating Amsterdam's labyrinthine streets, or just take in the sights on foot. For an unusual and memorable alternative to hotels, consider staying in a houseboat.

One of the world’s fashion capitals, Milan offers endless opportunities for chic shopping. Hit the artsy neighborhood of Brera for leather goods and Via Monte Napoleone for exclusive, expensive boutiques. The enchanting mosaics and glass vaults of Galleria Vittorio Emanuele II make shoppers feel like they’re wandering inside a painting. Take break from your spree to gape at the iconic Duomo, then grab tickets to a performance at La Scala. Post-opera, the Navigli district pulses with late-night activity.

Rome wasn't built in a day--and you'll need much more than a day to take in this timeless city. The city is a real-life collage of piazzas, open-air markets, and astonishing historic sites. Toss a coin into the Trevi Fountain, contemplate the Colosseum and the Pantheon, and sample a perfect espresso or gelato before spending an afternoon shopping at the Campo de’Fiori or Via Veneto. Enjoy some of the most memorable meals of your life here, too, from fresh pasta to succulent fried artichokes or a tender oxtail stew.