It seems like every time of year is "in season" in Lenox, a small Berkshire town that has been a popular retreat since the 19th century. In summer, picnic on the lawn at Tanglewood, the Boston Symphony Orchestra's summer home. In fall, when foliage peaks, take to the hiking and biking paths of the Pleasant Valley Sanctuary to immerse yourself in the vibrant colors of the mountains. Winter visitors enjoy skiing at a number of resorts and cross-country trails, and in spring, hikers and golfers practice their pastimes in splendid settings. Rejuvenating treatments and pampering, at the well-known Cranwell Spa, are favored all year long.

The Berkshires are home to an impressive collection of cultural and historic sights. Get your fill of music, art and theater at Tanglewood, the Boston Symphony's summer home, MASS MoCA, the country's largest contemporary art center, the Norman Rockwell Museum and the Williamstown Theatre Festival. Recreational opportunities also abound, including snowshoeing, snowboarding, skiing, rafting, kayaking, fishing and golf. The Berkshires are an easy drive, just two and a half hours from Boston and New York.

Westchester County, a collection of towns that serve as a popular suburb for the bordering New York City, is also the gateway to the Hudson River Valley, an area that promises a plethora of outdoor activities, from sailing to bird-watching to cross country skiing. The County also contains Rye Playland, a popular children's amusement park, historic sites from the American Revolution, the African American Heritage Trail and several famous houses, including Lyndhurst, a Gothic Revival mansion.

Located in the foothills of the Catskills Mountains, Cooperstown is proud to be a one-stoplight town, with quiet streets and charming old homes, sitting amidst the natural beauty of Otsego County. The area is home to the National Baseball Hall of Fame, the National Soccer Hall of Fame, the Fenimore Art Museum and the Glimmerglass Opera. Otsego County is also a popular destination for activities as diverse as antiquing, horseback riding and golf.

From its origins as a Connecticut River trading post in 1633, Hartford has become not only the state capital but also the insurance capital of the world, with a slew of historical attractions, a thriving arts and entertainment center, a revitalized riverfront and beautiful parks and public gardens. It was here that the lovable Huck Finn and Tom Sawyer were born in the imagination of celebrated author Mark Twain and immortalized on paper during the writer's Hartford years. Twain's home and those of fellow literary figures Harriet Beecher Stowe and Noah Webster are open to the public. The Wadsworth Atheneum, the oldest public art museum in the U.S., houses Pilgrim-Century furniture, the Amistad collection and a special treasure hunt system to entice kids to explore the museum's works. If your timing is right (end of June, beginning of July), you'll catch the Elizabeth Park rose gardens in bloom, but fall is also great for brilliant leaf colors, and spring yields colorful gardens and blossoming trees. For a bird's-eye view of the city, visit the observation deck of Travelers Tower, where you might also spot two resident falcons.

Saratoga Springs is one of those special getaway spots where everything is just, well, pretty close to perfect. The city's lovely tree-lined streets and grand old Victorians, porch swings swaying and gardens brimming with colorful flora bring to mind a gentler era. World-class horse racing, renowned performing arts and natural springs spas, plus 13 golf courses, 10 museums, a historic battlefield, fabulous boutiques, antiques and restaurants mean there is something for everyone. Relax at the Lincoln Mineral Baths, window shop in town and then it's off to the races. Walk everywhere, it's that kind of place. One of the oldest tourist destinations in the United States, Saratoga offers ample accommodation choices in elegant hotels, historic bed and breakfasts or comfortable inns. The only drawback is you may never want to leave.

Conquering New York in one visit is impossible. Instead, hit the must-sees – the Empire State Building, the Statue of Liberty, Central Park, the Metropolitan Museum of Art – and then explore off the beaten path with visits to The Cloisters or one of the city’s libraries. Indulge in the bohemian shops of the West Village or the fine dining of the Upper West Side. The bustling marketplace inside of Grand Central Station gives you a literal taste of the best the city has to offer.

Walk the Freedom Trail the first time you visit Boston and you'll quickly get a sense of this coastal city's revolutionary spirit and history. But make sure you also explore some of Boston's fine museums (try the Isabella Stewart Gardner, featuring masterpieces displayed in their collector's mansion) and old neighborhoods (like the North End, Boston's Little Italy). You can't claim to have experienced real Boston culture, though, until you've watched a Red Sox game from the bleachers.

From the National Mall’s monuments and memorials to vibrant neighborhoods filled with character and charm, DC is a world-class destination featuring breathtaking views, award-winning hotels and hundreds of free things to do. Experience outstanding performing arts at acclaimed theaters, shop in historic Georgetown, hear great live music at legendary venues, enjoy sporting entertainment from six professional franchises and be dazzled by a flourishing dining scene with Michelin-starred restaurants.

The windy city is a cornucopia of modern art, fine dining, cutting edge comedy, and die-hard sports fans. Snap a photo of your reflection in the silver Cloud Gate sculpture at Millennium Park before heading to Grant Park to get hit with the refreshing spray of Buckingham Fountain. There are dozens of museums and theater companies in Chicago, so a cultural experience is never hard to find. You’re sure to laugh your head off at the Second City Theater, the professional launch pad of many famous comedians.

With its gleaming skyscrapers set amid glittering lakes, Minneapolis makes for an attractive and fun getaway. A truly year-round destination, the city offers activities for every season. In winter, one can explore the downtown area through more than seven miles of glass-enclosed skyways. In addition to keeping you warm, they create a lively thoroughfare filled with specialty shops, restaurants and services. Whether you want to escape the winter cold or the summer warmth, the Mall of America offers shopping, dining and entertainment options for any time of the year and every member of the family. Art lovers have plenty to see at the Minneapolis Art Institute, Walker Art Center and the Frederick R. Weisman Art Museum, which all house world-renowned collections. The theater scene is thriving. With more than thirty theaters, Minneapolis has more seats per capita than any U.S. city except New York. See a Broadway show and enjoy dinner and live jazz at a fabulous restaurant. With kids in tow, check out the Science Museum of Minnesota, where visitors can produce their own video, or come face to face with a shark at the UnderWater Adventures Aquarium. In summer, the action moves outside. Known as "The City of Lakes," Minneapolis has 22 lakes located within city limits and many more in the surrounding area. In town, hordes of locals and tourists in-line skate or stroll around Lake Calhoun, stopping for ice cream along the way. Just outside of town, Fort Snelling State Park offers outdoor recreational activities from hiking to biking and golf to boating. No matter when you visit, Minneapolis offers lots for everyone to enjoy.

Whether you’re a high roller or a low-key lounger, Las Vegas has something to suit your vacation taste. Sample fare from top chefs and cornucopian buffets, try your luck at one of the world’s premier casinos, or take in a spectacular show. Just wandering the Strip is enough to get your heart pumping. Once you’ve had enough of the razzle-dazzle, wave hello to the toothy sea life at the Mandalay Bay Shark Reef, hike Red Rock Canyon, or visit the Neon Museum, where old signs take on new life.

Every neighborhood in San Francisco has its own personality, from the hippie chic of the Upper Haight to the hipster grit of the Mission. The Marina district boasts trendy bistros and postcard-perfect views of the Golden Gate Bridge, while Noe Valley offers quaint and quiet boutiques. Wave hello to the sea lions at Pier 39, and sample local cheese and charcuterie at the Ferry Building. Sit in on a yoga session in Dolores Park or marvel at the Dutch Windmill across from Ocean Beach.

From Shoreditch’s swaggering style to Camden’s punky vibe and chic Portobello Road, London is many worlds in one. The city’s energy means that no two days are the same. Explore royal or historic sites, tick off landmarks from your bucket list, eat and drink in exclusive Michelin-starred restaurants, enjoy a pint in a traditional pub, or get lost down winding cobbled streets and see what you stumble across – when it comes to London, the possibilities are endless.

This city, full of colorful homes, canals and bridges, is one of Europe's most picturesque capitals. Must-sees on any visitor's itinerary include the Anne Frank House, the Van Gogh Museum and the world's only floating flower market. Rent a bike and join thousands of locals navigating Amsterdam's labyrinthine streets, or just take in the sights on foot. For an unusual and memorable alternative to hotels, consider staying in a houseboat.

Sitting on the edge of the Baltic, the modern, cosmopolitan city of Helsinki is the World Design Capital for 2012. The beauty of the surrounding nature blends seamlessly with high-tech achievements and contemporary trends. Walking tours of the city center show layers of history, while modern architecture and cutting-edge style stake the city's claim to the future. Choose Helsinki during its endless summer days or get adventurous on crisp, snowy winter nights.