A short ride away from New York City on the Metro North commuter rail, Poughkeepsie sits on the banks of the Hudson River. The close proximity of Vassar College and the Culinary Institute of America guarantees the presence of fun boutiques and fine dining. Main Mall Row, a group of 1870s Renaissance Revival storefronts along Poughkeepsie's Main Street is on the National Register of Historic Places. The twenty-two surrounding parks provide the opportunity to take a relaxing break from city life.

A rich 300-year history, a thriving arts community and seemingly endless wilderness make this New York capital city on the Hudson River a great weekend getaway. Outdoor enthusiasts come here to ski, hike, canoe and fish; trout and small-mouth bass fishing is among the best in the U.S. Mountains surround the city, and the tapestry of golds and reds on an autumn day is breathtaking. The city is dominated by an elaborate 10-building complex that includes the State Capitol; the New York State Museum, with life-like dioramas such as American Indian life and an Adirondack logging operation; and the oval-shaped Empire State Performing Arts Center, nicknamed "The Egg." History buffs will enjoy the colonial homes, historic churches and museums, and can tour 18th-century mansions, like the Schuyler, a superb example of pre-Revolutionary War architecture. Whether nature or history is your passion, you'll find an abundance of both in this upstate New York gem.

The Berkshires are home to an impressive collection of cultural and historic sights. Get your fill of music, art and theater at Tanglewood, the Boston Symphony's summer home, MASS MoCA, the country's largest contemporary art center, the Norman Rockwell Museum and the Williamstown Theatre Festival. Recreational opportunities also abound, including snowshoeing, snowboarding, skiing, rafting, kayaking, fishing and golf. The Berkshires are an easy drive, just two and a half hours from Boston and New York.

Westchester County, a collection of towns that serve as a popular suburb for the bordering New York City, is also the gateway to the Hudson River Valley, an area that promises a plethora of outdoor activities, from sailing to bird-watching to cross country skiing. The County also contains Rye Playland, a popular children's amusement park, historic sites from the American Revolution, the African American Heritage Trail and several famous houses, including Lyndhurst, a Gothic Revival mansion.

Located in the foothills of the Catskills Mountains, Cooperstown is proud to be a one-stoplight town, with quiet streets and charming old homes, sitting amidst the natural beauty of Otsego County. The area is home to the National Baseball Hall of Fame, the National Soccer Hall of Fame, the Fenimore Art Museum and the Glimmerglass Opera. Otsego County is also a popular destination for activities as diverse as antiquing, horseback riding and golf.

Saratoga Springs is one of those special getaway spots where everything is just, well, pretty close to perfect. The city's lovely tree-lined streets and grand old Victorians, porch swings swaying and gardens brimming with colorful flora bring to mind a gentler era. World-class horse racing, renowned performing arts and natural springs spas, plus 13 golf courses, 10 museums, a historic battlefield, fabulous boutiques, antiques and restaurants mean there is something for everyone. Relax at the Lincoln Mineral Baths, window shop in town and then it's off to the races. Walk everywhere, it's that kind of place. One of the oldest tourist destinations in the United States, Saratoga offers ample accommodation choices in elegant hotels, historic bed and breakfasts or comfortable inns. The only drawback is you may never want to leave.

The windy city is a cornucopia of modern art, fine dining, cutting edge comedy, and die-hard sports fans. Snap a photo of your reflection in the silver Cloud Gate sculpture at Millennium Park before heading to Grant Park to get hit with the refreshing spray of Buckingham Fountain. There are dozens of museums and theater companies in Chicago, so a cultural experience is never hard to find. You’re sure to laugh your head off at the Second City Theater, the professional launch pad of many famous comedians.

With live music to be heard all across town, 24/7, 365 days a year, Music City lives up to its name. From honky-tonk bands jamming at Tootsie’s Orchid Lounge to songwriters in the round at the Bluebird Cafe and country music legends rocking the Grand Ole Opry, you never know who you might see. The creative spirit from Nashville's music landscape flows into the area's myriad art galleries, up-and-coming fashion scene, historic landmarks and chef-driven restaurants.

From the Magic Kingdom to magical spa treatments, Orlando sparkles with the promise of adventure. Spend a day exploring the world-famous Disney theme parks or screaming your head off on a Universal Studios roller coaster. For a less adrenaline-pumping afternoon, enjoy the quiet natural beauty of the Harry P. Leu Gardens or enjoy a seaweed scrub at a luxury day spa. Savor fresh and local ingredients at one of Orlando’s James Beard-nominated restaurants.

You may have all heard that everything is bigger in Texas. Well, Dallas does its best to fulfill that promise. You'll find several museums with vast art collections and fascinating specialty museums like The Sixth Floor Museum/Texas School Book Depository, which, though small in size, offers an immense amount of information about the assassination of John F. Kennedy. And of course, visit a local steakhouse for a terrific (and enormous) meal.

Houston hums with an energy and independent spirit all its own. A leading cultural and culinary destination in the South, the city is home to over 11,000 restaurants featuring cuisine from more than 70 countries. The thriving arts scene includes resident opera, ballet, symphony and theater companies. The Museum District houses 19 museums, all within walking distance. Be sure to visit Space Center Houston, where you can visit NASA’s Historic Mission Control at the Johnson Space Center.

Live music is the essence of Austin, but it isn’t even close to the whole story. With spectacular entertainment districts, ubiquitous culture and top-notch restaurants, Austin allows you to create your own soundtrack. Austin boasts more than 250 music venues, the world’s first James Beard Award-winning barbeque pitmaster, an eclectic arts scene and the unique migration of 1.5 million Mexican free-tailed bats. Take a look around and put the Live Music Capital of the World on your playlist.

Whether you’re a high roller or a low-key lounger, Las Vegas has something to suit your vacation taste. Sample fare from top chefs and cornucopian buffets, try your luck at one of the world’s premier casinos, or take in a spectacular show. Just wandering the Strip is enough to get your heart pumping. Once you’ve had enough of the razzle-dazzle, wave hello to the toothy sea life at the Mandalay Bay Shark Reef, hike Red Rock Canyon, or visit the Neon Museum, where old signs take on new life.

You’ll wonder why you don’t live in Portland after you’ve visited this laid-back and friendly city. With a reputation for manicured parks, eclectic nightlife, fine micro-breweries and distilleries, and nature that cuts right into the city, Portland’s a Pacific Northwest must-visit. Don’t miss the famous Japanese Garden, one of the largest and most beautiful of its kind outside of Japan.

Known as the home of “the happiest place on Earth,” there’s more to Anaheim than thrilling theme parks. Bring your appetite to the Anaheim Packing District and Center Street Promenade for some eclectic eateries and award-winning craft breweries. Explore the latest exhibits at the Muzeo Museum and Cultural Center. Enjoy live music at the all-new House of Blues, now at the Anaheim GardenWalk.

Hollywood beckons to tourists who long for a brush with Tinseltown glamor. Tour movie studios, slip your hands into the famous prints at the TCL Chinese Theatre, or indulge in a celeb sighting at one of LA’s white-hot nightspots. Spot your favorite star while shopping at The Grove, or forget all about the famous eye candy as you take in the iconic artwork at The Getty Center. For a different type of star-gazing, peek through the telescopes at the Griffith Observatory.