Perched on an island a mere 95 kilometers from the city of São Paulo, this bustling beach town seems a world away from the gargantuan urbanity of the state capital. Among its charms, Guarujá counts 23 separate, stunning beaches, all ripe for swimming, sunning and surfing. Families head to the beach at Enseada; singles, it's all about you at Pernambuco.

Set in a historic coffee region, Campinas combines the youthful energy of its universities with longstanding cultural traditions. Students keep cafés packed, nightlife is wild, and restaurants serve creative cuisine, while historic plantations and parks are just a short drive away.

A high perch on Mantiqueira Ridge means cool breezes and big views for Monte Verde, whose European-style houses lend the village its alpine charm. Hiking trails peel off in every direction, drawing both locals and visitors to lush stands of pines, rocky peaks, and waterfalls.

Located in the South Pacific more than 2,000 miles off the Chilean coast, Easter Island’s not the easiest place to reach. (If you’re interested, the easiest access is by air from Santiago or Tahiti.) But isolation has helped preserve the 1,500-year-old mysterious congregation of volcanic rock sculptures (maoi) that’s the island’s biggest claim to fame. After exploring the unique landscape, relax on an uncrowded beach and ponder one of the most mysterious places on Earth.

Miami is hot hot hot! And it’s not just the sultry weather. Here, the nightlife is scorching, thanks to a strong Latin influence and spicy salsa culture. Dance the noche away in a nightclub, or indulge in a fancy meal at one of the city’s celebrity-owned restaurants. By day, hit the beach of course, or have yourself a walkabout, taking in Miami’s colorful art deco architecture. Grab a Cuban sandwich in Little Havana, then ride the vintage carousel at Virginia Key Beach Park.

Fort Lauderdale’s canals and charm have earned it the nickname “The Venice of America.” The beaches offer 23 miles of golden sand, lively with the spirited antics of happy vacationers. Sail the blue-green waters on a chartered catamaran, or dive beneath the surface to meet-and-greet the local sea life. Shopping and dining al fresco on Las Olas Boulevard is one of Fort Lauderdale’s greatest pleasures, thanks to adorable shops and prime people-watching.

Cape Canaveral and the neighboring Kennedy Space Center have become synonymous with space travel in the U.S. The first phases of the U.S. space program were conducted at Cape Canaveral Air Force Station, now a historic landmark and home to the Air Force Space and Missile Museum, before operations were moved to Kennedy. In addition to its Space Coast reputation, Canaveral also boasts the historic Cape Canaveral Lighthouse, Merritt Island National Wildlife Refuge and Canaveral National Seashore.

From the Magic Kingdom to magical spa treatments, Orlando sparkles with the promise of adventure. Spend a day exploring the world-famous Disney theme parks or screaming your head off on a Universal Studios roller coaster. For a less adrenaline-pumping afternoon, enjoy the quiet natural beauty of the Harry P. Leu Gardens or enjoy a seaweed scrub at a luxury day spa. Savor fresh and local ingredients at one of Orlando’s James Beard-nominated restaurants.

Dubbed the Queen City, Charlotte reigns over a 300-square-mile (482-square-kilometer) hodgepodge of neighborhoods that spin out from the banks of the Catawba River. From brewery-heavy art districts to historical corridors dripping in charm, consider Charlotte a crowd pleaser.

Atlanta has been dubbed everything from the "capital of the new South" and "the next international city" to "the best place to do business." It's also a great place to visit. Fueled by the prosperity of local mega companies like Coca Cola and Holiday Inn, the prestige of hosting the 1996 Summer Olympic Games and the energy of young upwardly mobile types who have migrated to the city in droves - Atlanta is on fire. And this time it's a good thing. From world-class restaurants and a myriad of cultural attractions to a hip nightlife and sporting events galore, the city is cosmopolitan in every sense of the word. But Atlanta has also managed to maintain its historic character. Stop by the Atlanta History Center or visit the Martin Luther King Jr. Historical Site, a moving tribute to an American icon. Browse through the former home of famous author Margaret Mitchell or pop into the Jimmy Carter Library and Museum for details on the life and times of the former president and his family. Whether you choose modern urban endeavors or old southern pleasures, Atlanta will not disappoint.

Walk the Freedom Trail the first time you visit Boston and you'll quickly get a sense of this coastal city's revolutionary spirit and history. But make sure you also explore some of Boston's fine museums (try the Isabella Stewart Gardner, featuring masterpieces displayed in their collector's mansion) and old neighborhoods (like the North End, Boston's Little Italy). You can't claim to have experienced real Boston culture, though, until you've watched a Red Sox game from the bleachers.

With live music to be heard all across town, 24/7, 365 days a year, Music City lives up to its name. From honky-tonk bands jamming at Tootsie’s Orchid Lounge to songwriters in the round at the Bluebird Cafe and country music legends rocking the Grand Ole Opry, you never know who you might see. The creative spirit from Nashville's music landscape flows into the area's myriad art galleries, up-and-coming fashion scene, historic landmarks and chef-driven restaurants.