Saint Augustine is a luxurious, romantic vacation spot—you’ll find classic hotels and intimate restaurants. Those can be a dime a dozen, though. What sets Saint Augustine apart is its history—it’s the oldest European settlement in the U.S. And nowhere else in the world can you taste the waters of the Fountain of Youth Archeological Park (where Ponce de Leon may have landed). Who knows, if you vacation here, maybe you won’t need that Botox!

Gatlinburg, at the heart of Great Smoky Mountains National Park, is an ideal base for a family looking to explore the park's numerous offerings. After you've gone hiking, fishing, rafting or horseback riding, ride an elevator 342 feet to the top of the Gatlinburg Space Needle for stunning views of the Smokies. There's also an amusement center next door with nifty rides and games.

Greenville, South Carolina, is anchored by what Forbes Magazine calls one of America's Best Downtowns. Featuring a one-of-a-kind "floating" suspension bridge and set against the scenic Blue Ridge Mountains, Greenville boasts a thriving arts scene, hundreds of restaurants, shops and boutiques, popular annual festivals, numerous historic sites and museums housing significant art collections. Excellent interstate service and a user-friendly international airport make access easy.

Each year, horse enthusiasts hoof it to Louisville and Churchill Downs, the legendary home of the Kentucky Derby. In addition to equestrian endeavors and bluegrass roots, Louisville boasts a range of exciting attractions the whole family can enjoy. Stroll through Central Park, in the historic district, to people-watch and get a real feel for the city. Visit other nearby parks for hiking, biking and fossil finding. Baseball fans will love the Louisville Slugger Museum, a celebration of the sport's legends. The museum is easy to spot, just look for the humongous bat that leans against the building.

Hilly Cincinnati boasts a thriving arts scene, major league sports teams, a world-class zoo and aquarium and a revitalized riverfront with shopping, clubs and restaurants. Located on the Ohio River in southwestern Ohio, Cinci claims more than 4,000 restaurants, and more chili restaurants than any other city in the world. Adrenaline-junkies will want to visit the nearby Kentucky Speedway and Paramount's Kings Island, home of the tallest and fastest wooden roller coaster in the world.

The windy city is a cornucopia of modern art, fine dining, cutting edge comedy, and die-hard sports fans. Snap a photo of your reflection in the silver Cloud Gate sculpture at Millennium Park before heading to Grant Park to get hit with the refreshing spray of Buckingham Fountain. There are dozens of museums and theater companies in Chicago, so a cultural experience is never hard to find. You’re sure to laugh your head off at the Second City Theater, the professional launch pad of many famous comedians.

If you're looking for a getaway that's fun for the whole family and easy on your pocket, look no further than Raleigh. With more than 20 free attractions, this stately and energetic capital city offers an affordable way to enjoy history, culture and the good old outdoors. Spend the day hopping between the three state museums of art, history and natural sciences: all offer free admission. Visitors are free to wander around the grounds of the State Capitol, where they can also observe the legislative process. Stroll past the graves of Civil War generals at a historic cemetery or meander along cobblestone streets of City Market. Shop for the greenest broccoli, reddest apples and tastiest homemade treats around at the State Farmers Market. With over 150 parks, lakes and green ways in Raleigh alone, there is ample opportunity to enjoy golf, biking, swimming, boating and other outdoor adventures.

Detroit is an amazing destination for your next weekend getaway. If exploring is your thing, hop on a bike and meet new friends on the Slow Roll bike tour (you’ll find a unique perspective on the city, and the slow pace is perfect for all skill levels). And while you may not think of Detroit as wine country, the newly opened Detroit Vineyards is one of the country’s largest urban wineries, crafting superior wines right in the heart of the city. Grab your glass and make a toast to the weekend!

Walk the Freedom Trail the first time you visit Boston and you'll quickly get a sense of this coastal city's revolutionary spirit and history. But make sure you also explore some of Boston's fine museums (try the Isabella Stewart Gardner, featuring masterpieces displayed in their collector's mansion) and old neighborhoods (like the North End, Boston's Little Italy). You can't claim to have experienced real Boston culture, though, until you've watched a Red Sox game from the bleachers.

Montreal, c’est si bon! This French-speaking city is considered the cultural capital of Canada, and is a cosmopolitan celebration of Québécois style. A horse-drawn carriage ride around the cobblestone streets and grand buildings of Vieux-Montréal will give you a taste of European flavor. The Basilique Notre-Dame is a confection of stained glass, and the Plateau Mont-Royal district will delight you with its quaint boutiques and cafés. Dig in to a massive plate of poutine to fuel up for a tour of the epic Olympic Park.