Unassuming Brussels is the capital of Belgium, Flanders and Europe. Medieval Grand-Place, is indeed grand, with many 17th-century buildings and daily flower markets. Reopened in 2006, the Atomium, Brussels' Eiffel Tower, provides great views, inside and out. Architecture fans should visit Musee Horta, home of Belgian master architect Victor Horta. St. Gery's clubs and bars are packed year-round. Seafood eateries abound in Ste. Catherine. Walk, rather than get snarled up in traffic, in the narrow streets.

The old Burgundian university town of Leuven offers a range of adventures for overnight visitors or day-trippers from Bruges and Brussels. Tourists will find everything from gastronomic tours to architectural gems like the Gothic Town Hall. Nature lovers won’t be disappointed. The Kruidtuin Botanical Garden’s herbal gardens are the oldest in Belgium, and Heverleebos, a “city wood,” offers a respite for urban dwellers. The exploring is easy in Leuven, on foot or on one of the ubiquitous bikes.

Lively Antwerp is a hidden gem. Its medieval streets, Renaissance monuments and vibrant nightlife tend to be overshadowed by its reputation as center of the diamond trade and as the world's fifth-largest port. Biking is a popular choice for getting around this stylish Flemish city. See thousands of Old Masters at the Royal Museum and Rubens House. Experience the bustle of life at the Grote Markt. Marvel at the art and architecture of the still unfinished Cathedral of Our Lady, started in 1351.

Belgium's fourth-largest - and most beautiful - city is home to a quarter of a million people and a flourishing flower export trade. An important port, Ghent's city center is a pedestrian area that is like a museum to early Flemish architecture and a testament to the city's medieval might. Impressive Gothic sites, such as dramatic St. Bavo's Cathedral and the Castle of the Counts, inspire awe. The works of Flemish masters are housed in the distinguished Museum voor Schone Kunst.

What could be more romantic and inspiring than a place that looks like a backdrop for a fairy tale? The medieval overtones of Bruges’ cobblestone streets lead to countless historical, architectural and artistic wonders. Marvel at ornate houses lining intricate canals, and understand why this is a favorite destination for all types of travelers. The whole city emanates an appreciation of the past, a love of the present, and enthusiasm for the future. Don’t miss Hof Bladelin, Groeninge Museum, Church of Our Lady, and Belfry and Market Halls.

Touching Belgium on its west and just a few miles from Germany to the east, Maastricht is the capital of Holland’s southernmost region, Limburg. A town rich in history and culture, Maastricht boasts two wonderful town squares: Vrijthof, with Sint-Servaas Church, Sint-Jan's Cathedral and many bars, cafes and restaurants; and Markt, home to the town hall and, on Wednesday and Friday mornings, a fantastic vendor market. The city’s Vestigingswerken, or old town fortifications, are another big draw.

At Christmastime, the entire city of Valkenburg seems to sparkle with festive light. The annual underground Christmas market is a hallmark of the city, lasting from mid-November through December 23. It’s held in the Velvet Caves, a maze of 12th-century passageways that lies beneath the remains of Valkenburg’s hilltop castle. The caves and castle draw visitors year-round. Valkenburg is a biking city. It's a great base for cycling tours and is a two-time stage finish site for the Tour de France.

Eindhoven is one of the oldest cities in the Netherlands, but you’d never know it from the high-tech industry and cutting-edge design it’s currently known for. If you have kids obsessed by all things wheeled, they will love the trucks at the DAF Museum.

Ultramodern towers define Riyadh's skyline, hinting at the Saudi capital's sophisticated culture, shopping, and dining. Prayer times set the pace for life in one of the country's most conservative cities, and gleaming architecture blends with historic landmarks from the kingdom's earliest years.

The shining jewel of Qatar, Doha is a multicultural city, home to most of the country's population as well as expatriate communities from a range of origins. Shopping abounds in the city's plentiful malls, while the Corniche impresses visitors with picturesque architecture and dazzling views of the harbor. Doha boasts myriad cultural facilities, including the futuristic Education City and the National Museum.

Dubai is a destination that mixes modern culture with history, adventure with world-class shopping and entertainment. Catch a show at the Dubai Opera, see downtown from atop the Burj Khalifa and spend an afternoon along Dubai Creek exploring the gold, textile and spice souks. If you’re looking for thrills, you can float above the desert dunes in a hot air balloon, climb aboard a high-speed ride at IMG Worlds of Adventure or skydive over the Palm Jumeirah.

Strung below craggy mountains, the Omani capital of Muscat is one of the Middle East’s oldest and most picturesque cities. Between its corniches and modern quarter are Portuguese-built forts, blue-domed mosques, royal palaces, and souks, all heavy with the sense of a lost Arabia.

Walk the Freedom Trail the first time you visit Boston and you'll quickly get a sense of this coastal city's revolutionary spirit and history. But make sure you also explore some of Boston's fine museums (try the Isabella Stewart Gardner, featuring masterpieces displayed in their collector's mansion) and old neighborhoods (like the North End, Boston's Little Italy). You can't claim to have experienced real Boston culture, though, until you've watched a Red Sox game from the bleachers.

Conquering New York in one visit is impossible. Instead, hit the must-sees – the Empire State Building, the Statue of Liberty, Central Park, the Metropolitan Museum of Art – and then explore off the beaten path with visits to The Cloisters or one of the city’s libraries. Indulge in the bohemian shops of the West Village or the fine dining of the Upper West Side. The bustling marketplace inside of Grand Central Station gives you a literal taste of the best the city has to offer.

Packed with historic landmarks, bustling eateries, and manicured parks, the vibrant city of Lahore exudes culture at every corner. From soaring minarets and colorful facades to street-level stalls selling flavorful Punjabi favorites, the increasingly cosmopolitan city radiates with energy.

The windy city is a cornucopia of modern art, fine dining, cutting edge comedy, and die-hard sports fans. Snap a photo of your reflection in the silver Cloud Gate sculpture at Millennium Park before heading to Grant Park to get hit with the refreshing spray of Buckingham Fountain. There are dozens of museums and theater companies in Chicago, so a cultural experience is never hard to find. You’re sure to laugh your head off at the Second City Theater, the professional launch pad of many famous comedians.

With live music to be heard all across town, 24/7, 365 days a year, Music City lives up to its name. From honky-tonk bands jamming at Tootsie’s Orchid Lounge to songwriters in the round at the Bluebird Cafe and country music legends rocking the Grand Ole Opry, you never know who you might see. The creative spirit from Nashville's music landscape flows into the area's myriad art galleries, up-and-coming fashion scene, historic landmarks and chef-driven restaurants.

From the Magic Kingdom to magical spa treatments, Orlando sparkles with the promise of adventure. Spend a day exploring the world-famous Disney theme parks or screaming your head off on a Universal Studios roller coaster. For a less adrenaline-pumping afternoon, enjoy the quiet natural beauty of the Harry P. Leu Gardens or enjoy a seaweed scrub at a luxury day spa. Savor fresh and local ingredients at one of Orlando’s James Beard-nominated restaurants.