The festive city of San Juan is the perfect place to experience true Puerto Rican culture. Get to know its roots by exploring the vibrant neighborhood of El Viejo San Juan (Old San Juan), which consists mostly of Spanish colonial buildings. Flesh out your self-guided history lesson with a visit to El Castillo San Felipe del Morro, a 16th century citadel that’s a UNESCO World Heritage Site. Then reward yourself with a cooling dip at Luquillo or Carolina Beach, then a tasty tour of the Bacardi rum plant.

Miami is hot hot hot! And it’s not just the sultry weather. Here, the nightlife is scorching, thanks to a strong Latin influence and spicy salsa culture. Dance the noche away in a nightclub, or indulge in a fancy meal at one of the city’s celebrity-owned restaurants. By day, hit the beach of course, or have yourself a walkabout, taking in Miami’s colorful art deco architecture. Grab a Cuban sandwich in Little Havana, then ride the vintage carousel at Virginia Key Beach Park.

Does time ever pass in the Florida Keys? Everyone and everything in Key West seems to go at its own pace, right down to the ice melting slooooowly in your margarita glass. Of course, it’s not all limes and leisure – Key West is known as the “Winter White House” because of its appeal to visiting U.S. presidents, and the island has been home to literary greats like Ernest Hemingway and Tennessee Williams. The diving here is phenomenal, as is the kid-friendly Florida Keys Eco-Discovery Center.

Get the experience of visiting two island colonies in the same 37 square miles. Saint Maarten/Saint Martin's spicy marriage of Caribbean, French and Dutch cultures matches its physical diversity: the island is both urban and untamed, with rain forest-like landscapes, white beaches, and amazing caves and wildlife.

Cartagena, a gorgeous fishing village on Colombia's Caribbean coast, has excellent beaches, a historic old town (that's entirely walkable) and beautiful colonial architecture. It's also one of the safest places in the country, so it's no wonder it's a popular port of call for cruise ships. Need a break from exploring the cobblestone streets? Stop at an outdoor cafe for excellent pastries and people-watching.

Isla Mujeres offers a wide variety of tempting options for beach lovers, and is a relative bargain. Snorkel with tropical fish amid coral reefs, skim the blue waters by kayak or boat, or windsurf along the shores of soft, sandy beaches. On land, you can sunbathe, dine on seafood, dance to Latin rhythms, tour on a moped or belly up to the bar for fresh, delicious drinks.

Sunny Cancun has much more to offer than its party-town reputation might suggest. Plenty of gorgeous, drama-free family resorts cater to folks who want to experience the tropical Yucatan climate. There are significant Mayan ruins here, such as El Rey and the Yamil Lu’um, a crumbling tower of pale gray stone. Learn more about this ancient civilization at the Museo Maya de Cancun. For a literal taste of Mexico, take a tour of the Museo Sensorial del Tequila.

As a well-known destination for both spring breakers and A-list travelers in need of a getaway, Cabo San Lucas has definite vacation cred. The beaches here range in temperament, from the serene waters of the Sea of Cortez and Playa del Amor to the kickin’ waves of Zippers, a surfing paradise. If you care to romp with locals, head to the coves and rock formations of the Cannery beaches. Kids will have a blast communing with the local animals by swimming with dolphins or taking a camel ride through the Desert Park Natural Reserve.

Whether you’re a high roller or a low-key lounger, Las Vegas has something to suit your vacation taste. Sample fare from top chefs and cornucopian buffets, try your luck at one of the world’s premier casinos, or take in a spectacular show. Just wandering the Strip is enough to get your heart pumping. Once you’ve had enough of the razzle-dazzle, wave hello to the toothy sea life at the Mandalay Bay Shark Reef, hike Red Rock Canyon, or visit the Neon Museum, where old signs take on new life.

San Diego embodies laid-back California culture, complete with a Boardwalk, surfing communities, and outstanding Mexican food. Breathe in the fresh ocean air at Sunset Cliffs Natural Park, then gobble down a fresh fish taco at a La Jolla seafood joint. The naval aircrafts at the USS Midway Museum will have you standing at attention. A free Sunday concert at the Spreckels Organ Pavilion is the perfect way to unwind after a Saturday night bar-hop in the thumping Gaslamp Quarter.