With its hilltop castle and medieval architecture, Guimaraes looks like it's straight out of a fairy tale. Said to be Portugal's birthplace, the city boasts UNESCO status and houses manicured gardens, a historic palace, and a 13th-century church.

Sometimes called the “Portuguese Rome” for its many churches, Braga is an ancient town in northwest Portugal. Its history and livelihood are tied to Christianity dating to the 3rd century. The city’s 12th-century Sé (Cathedral) is still one of the most popular attractions. Just outside of town lies the renowned Bom Jesus de Monte pilgrimage sanctuary, with its striking Baroque stairway. After dark, the stoic town turns upside down, with a rich nightlife thanks to its many university students.

Hailed as the Portuguese equivalent to Venice, maritime Aveiro is perched on the shores of a coastal lagoon. Brightly-colored moliceiros (traditional boats) cruise the city's canal network, while Aveiro's old town boasts buildings decorated with traditional azulejo tiles.

A self-guided walking tour is the best way to appreciate the stunning architecture of Viana do Castelo. The buildings date from several different centuries so styles vary: highlights include the early 20th-century Basilica of Santa Luzia; the 16th-century fountain and former city hall building at the Praça da República; the gothic Cathedral on the Largo da Matriz; and the Monument to Caramuru and Paraguaçu, built just a few years ago in 2009.

Brimming with both history and natural wonder, Northern Portugal is home to Porto, the city that gave the country its name, as well as the important ancient town of Braga. Also here is Peneda-Gerês, Portugal’s only national park, a gorgeous wilderness area of mountains, gorges, water features and wildlife. Many picturesque villages and manor houses dot the countryside. Two areas are UNESCO World Heritage Sites: the Alto Douro Wine Region, and the Paleolithic rock art in the Côa Valley.

Often overlooked in favor of Porto and Lisbon, Coimbra sits on the banks of the winding Mondego River. After a day spent among the city's medieval architecture and grand university buildings, it's easy to see why Coimbra was Portugal's capital for over a century.

Barcelona feels a bit surreal – appropriate, since Salvador Dali spent time here and Spanish Catalan architect Antoni Gaudí designed several of the city’s buildings. Stepping into Gaudí’s Church of the Sacred Family is a bit like falling through the looking glass - a journey that you can continue with a visit to Park Güell. Sip sangria at a sidewalk café in Las Ramblas while watching flamboyant street performers, then create your own moveable feast by floating from tapas bar to tapas bar.

Lingering over pain au chocolat in a sidewalk café, relaxing after a day of strolling along the Seine and marveling at icons like the Eiffel Tower and the Arc de Triomphe… the perfect Paris experience combines leisure and liveliness with enough time to savor both an exquisite meal and exhibits at the Louvre. Awaken your spirit at Notre Dame, bargain hunt at the Marché aux Puces de Montreuil or for goodies at the Marché Biologique Raspail, then cap it all off with a risqué show at the Moulin Rouge.

From Shoreditch’s swaggering style to Camden’s punky vibe and chic Portobello Road, London is many worlds in one. The city’s energy means that no two days are the same. Explore royal or historic sites, tick off landmarks from your bucket list, eat and drink in exclusive Michelin-starred restaurants, enjoy a pint in a traditional pub, or get lost down winding cobbled streets and see what you stumble across – when it comes to London, the possibilities are endless.

This city, full of colorful homes, canals and bridges, is one of Europe's most picturesque capitals. Must-sees on any visitor's itinerary include the Anne Frank House, the Van Gogh Museum and the world's only floating flower market. Rent a bike and join thousands of locals navigating Amsterdam's labyrinthine streets, or just take in the sights on foot. For an unusual and memorable alternative to hotels, consider staying in a houseboat.

Rome wasn't built in a day--and you'll need much more than a day to take in this timeless city. The city is a real-life collage of piazzas, open-air markets, and astonishing historic sites. Toss a coin into the Trevi Fountain, contemplate the Colosseum and the Pantheon, and sample a perfect espresso or gelato before spending an afternoon shopping at the Campo de’Fiori or Via Veneto. Enjoy some of the most memorable meals of your life here, too, from fresh pasta to succulent fried artichokes or a tender oxtail stew.

Conquering New York in one visit is impossible. Instead, hit the must-sees – the Empire State Building, the Statue of Liberty, Central Park, the Metropolitan Museum of Art – and then explore off the beaten path with visits to The Cloisters or one of the city’s libraries. Indulge in the bohemian shops of the West Village or the fine dining of the Upper West Side. The bustling marketplace inside of Grand Central Station gives you a literal taste of the best the city has to offer.

Dubai is a destination that mixes modern culture with history, adventure with world-class shopping and entertainment. Catch a show at the Dubai Opera, see downtown from atop the Burj Khalifa and spend an afternoon along Dubai Creek exploring the gold, textile and spice souks. If you’re looking for thrills, you can float above the desert dunes in a hot air balloon, climb aboard a high-speed ride at IMG Worlds of Adventure or skydive over the Palm Jumeirah.

The windy city is a cornucopia of modern art, fine dining, cutting edge comedy, and die-hard sports fans. Snap a photo of your reflection in the silver Cloud Gate sculpture at Millennium Park before heading to Grant Park to get hit with the refreshing spray of Buckingham Fountain. There are dozens of museums and theater companies in Chicago, so a cultural experience is never hard to find. You’re sure to laugh your head off at the Second City Theater, the professional launch pad of many famous comedians.

Known as the safari capital of Africa, Nairobi is an energetic, modern city that serves as a fascinating introduction to both wildlife and nightlife. Music clubs pulse with life, shops and markets bustle, and a mélange of restaurants will tempt your palate in this former Maasai watering hole. Top sights include the Karen Blixen Museum, Giraffe Centre and the black rhinos of Nairobi National Park. The compact city center is safe to walk in and taxis make other areas accessible.