Popular in the late 18th and early 19th century with luminaries such as Strauss, Wagner, Kafke, Freud, Twain and Edward VII, this sprightly spa town is a charming spot. Delicately painted spa houses and hotels tiptoe up the lush, forested mountainsides. One hundred mineral springs with high carbon dioxide and iron content confetti the town and nearby hillsides, many with neat colonnades and stately pavilions. The most famed is the cupola-capped and colonnade-adorned Krizovy pramen.

The Czech Republic's most famed spa destination, Karlovy Vary - or Carlsbad - saw 200 spa houses sprout by the end of the 1500s. The springs in this idyllic, lush, peaceful Tepla valley are said to cure an almanac's worth of metabolic and gastric issues. Visitors still flock to this town of Baroque and Art Nouveau buildings. Five beautiful Colonnades straddle hot springs where visitors try aquatherapy and drink the mineral-rich water. The town also has a respected international film festival.

The bohemian allure and fairytale features of Prague make it a perfect destination for beach-weary vacationers who want to immerse themselves in culture. You could devote an entire day to exploring Prazsky hrad (Prague Castle), then refueling over a hearty dinner at a classic Czech tavern. Spend some time wandering the Old Town Square before heading over to gape at The Old Town Hall and Astronomical Clock. Prague’s best bars are found in cellars, where historic pubs set the scene for a night of traditional tippling.

Known by the German name "Budweis" in the 19th century, the south Bohemian city of Ceske Budejovice has been a center of brewing since the 13th century. The original inspiration for the American version, Budwar or Budweiser beer remains one of the most popular in the country. The vast, beautiful Námesti Otakar II square is the site of stately Renaissance, Gothic and Baroque buildings, including the beautiful 1727 town hall. Buses and trolleys link areas, and cycling paths run through the city.

Lingering over pain au chocolat in a sidewalk café, relaxing after a day of strolling along the Seine and marveling at icons like the Eiffel Tower and the Arc de Triomphe… the perfect Paris experience combines leisure and liveliness with enough time to savor both an exquisite meal and exhibits at the Louvre. Awaken your spirit at Notre Dame, bargain hunt at the Marché aux Puces de Montreuil or for goodies at the Marché Biologique Raspail, then cap it all off with a risqué show at the Moulin Rouge.

Most visitors to Fiumicino arrive by plane and immediately continue on to Rome, but—in addition to being home to Italy’s busiest airport—the coastal town doubles as a beach resort during the summer months. There’s also Ostia Antica archaeological site, which is just a short drive away.

From Shoreditch’s swaggering style to Camden’s punky vibe and chic Portobello Road, London is many worlds in one. The city’s energy means that no two days are the same. Explore royal or historic sites, tick off landmarks from your bucket list, eat and drink in exclusive Michelin-starred restaurants, enjoy a pint in a traditional pub, or get lost down winding cobbled streets and see what you stumble across – when it comes to London, the possibilities are endless.

Walk the Freedom Trail the first time you visit Boston and you'll quickly get a sense of this coastal city's revolutionary spirit and history. But make sure you also explore some of Boston's fine museums (try the Isabella Stewart Gardner, featuring masterpieces displayed in their collector's mansion) and old neighborhoods (like the North End, Boston's Little Italy). You can't claim to have experienced real Boston culture, though, until you've watched a Red Sox game from the bleachers.

Conquering New York in one visit is impossible. Instead, hit the must-sees – the Empire State Building, the Statue of Liberty, Central Park, the Metropolitan Museum of Art – and then explore off the beaten path with visits to The Cloisters or one of the city’s libraries. Indulge in the bohemian shops of the West Village or the fine dining of the Upper West Side. The bustling marketplace inside of Grand Central Station gives you a literal taste of the best the city has to offer.

From the National Mall’s monuments and memorials to vibrant neighborhoods filled with character and charm, DC is a world-class destination featuring breathtaking views, award-winning hotels and hundreds of free things to do. Experience outstanding performing arts at acclaimed theaters, shop in historic Georgetown, hear great live music at legendary venues, enjoy sporting entertainment from six professional franchises and be dazzled by a flourishing dining scene with Michelin-starred restaurants.

The windy city is a cornucopia of modern art, fine dining, cutting edge comedy, and die-hard sports fans. Snap a photo of your reflection in the silver Cloud Gate sculpture at Millennium Park before heading to Grant Park to get hit with the refreshing spray of Buckingham Fountain. There are dozens of museums and theater companies in Chicago, so a cultural experience is never hard to find. You’re sure to laugh your head off at the Second City Theater, the professional launch pad of many famous comedians.