From Shoreditch’s swaggering style to Camden’s punky vibe and chic Portobello Road, London is many worlds in one. The city’s energy means that no two days are the same. Explore royal or historic sites, tick off landmarks from your bucket list, eat and drink in exclusive Michelin-starred restaurants, enjoy a pint in a traditional pub, or get lost down winding cobbled streets and see what you stumble across – when it comes to London, the possibilities are endless.

This city, full of colorful homes, canals and bridges, is one of Europe's most picturesque capitals. Must-sees on any visitor's itinerary include the Anne Frank House, the Van Gogh Museum and the world's only floating flower market. Rent a bike and join thousands of locals navigating Amsterdam's labyrinthine streets, or just take in the sights on foot. For an unusual and memorable alternative to hotels, consider staying in a houseboat.

A gorgeous spot that’s a convenient day trip from Milan, Lake Como recently earned fame as home to Hollywood star George Clooney. But celeb-spotting aside, it’s known for jaw-dropping natural beauty, elegant old villas—and the scenic towns surrounding the lake. Check out Varenna, Bellagio, and Menaggio, which offer great views, historic churches, and water-based activities such as ferries and passenger-only boats.

One of the world’s fashion capitals, Milan offers endless opportunities for chic shopping. Hit the artsy neighborhood of Brera for leather goods and Via Monte Napoleone for exclusive, expensive boutiques. The enchanting mosaics and glass vaults of Galleria Vittorio Emanuele II make shoppers feel like they’re wandering inside a painting. Take break from your spree to gape at the iconic Duomo, then grab tickets to a performance at La Scala. Post-opera, the Navigli district pulses with late-night activity.

You'll find rugged beauty and a slow pace in the Cinque Terre. Named for the five towns of Monterosso, Vernazza, Corniglia, Manarola and Riomaggiore, this portion of the Italian Riviera is a UNESCO World Heritage Site. Cars aren't allowed, so take local trains or ferries to go from town to town—or walk one of the spectacular trails that connect them.

This Tuscan hill town will transport you back to the Middle Ages. Siena's grand cathedral, built in the 1200s, has treasured artworks and marvelous marble floors. The Piazza del Campo, the main town square, is a UNESCO World Heritage Site. It's also home to the Palio, perhaps the most infamous horserace in the world. No goofy hats and mint juleps here—this is a medieval tradition involving bareback riders racing on cobblestones (so as you might imagine, it's quite dangerous). Siena is an easy daytrip by train from Florence, just 43 miles away.

The town that gave the country (and port wine) its very name, Porto is Portugal’s second-largest metropolis after Lisbon. Sometimes called Oporto, it's an age-old city that has one foot firmly in the industrial present. The old town, centered at Ribeira, was built on the hills overlooking the Douro River, and today is a UNESCO World Heritage Site. The 14th-century São Francisco church is a main attraction, as are the local port wine cellars, mostly located across the river at Vila Nova de Gaia.

Land of Mermaids. Land of Orange and Lemon Groves. Land of Colors. This small city in Campania has earned a plethora of alluring names. Famed for its sea cliffs, the town's steep slopes look out over azure waters to Ischia, Capri and the Bay of Naples. The birthplace of Limoncello liqueur offers some good diving, great sea fishing, boat cruises and appetizing restaurants. Excellent hiking trails cross the peninsula. Rent a car or take a taxi if the steep streets look too intimidating.

The museums of Lisbon celebrate the rich history and culture of this Portuguese capital city. The Maritime Museum is perfect for kids (and grown-ups!) who adore all things nautical, while the Casa-Museu Dr. Anastácio Gonçalves is a hidden gem of colorful artwork. To fully appreciate the city’s dramatic stone architecture you can take a guided walking tour, or customize your own tour, making sure to visit the Padrao dos Descobrimentos, the Mosteiro dos Jeronimos, and the UNESCO World Heritage site the Torre de Belem.

Catania has been a prize of many empires over the centuries, from Greeks to Romans to Arabs to Normans to Spaniards (to name a few). But its citizens have a more dangerous enemy right in their backyard—Mount Etna, Europe's largest and most active volcano, which destroyed the city with earthquakes and lava flows in 1693. Look closely at the baroque buildings dating from after the eruption—you'll notice a creative use of lava.