Once a mere pineapple patch, the red-dirt island of Lanai is an oasis of calm. Reaching the island is difficult - no direct flights from the mainland - but once you arrive, the tropical surroundings are the ideal backdrop for snorkeling and scuba diving, swimming in Hulopoe Bay (a marine preserve), whale watching, horseback riding, golfing, hiking, four-wheeling and exploring the red spires of the Garden of the Gods. The 1920s-era town is small but quaint, and the locals go out of their way to be friendly.

Lahaina, the former Hawaiian capital, was the center of the global whaling trade, and its Historic District is a National Historic Landmark. Traditional Hawaiian luaus, surf lessons and tours on horseback are fun, but let’s be realistic—you wouldn’t be in Hawaii if you didn’t want to go to the beach. Try Ka’anapali Beach, one of Maui’s best.

Kapaa, also spelled Kapa'a, means "solid" in Hawaiian. Travelers find this small town, nestled at the base of Nounou (the Sleeping Giant) Mountain on Kauai tourist friendly with its diverse array of hotels, shopping centers, and restaurants. The Kinipopo Shopping Village is a favorite for its fun eateries and small keepsake shops. Look for the "Kauai Made" logo for products made by local craftsmen using traditional materials. Kappa also offers water sports, including water skiing and kayaking.

Lihue, Kauai's capital city, is also served by the island's only airport, making it the most popular port of entry to Kauai and a hub of industry on this small island. However, Lihue retains its island charm and emerald beauty despite its urbanization. Spend the day sunbathing and dipping into the temperate waters at Kalapaki Beach before enjoying a luau at Kilohana Plantation. Step out of town to witness breathtaking Wailua Falls cascading over tiered stone to a drop of 80 feet.

Hit the casinos, watch big-name entertainment and stay at a themed hotel. Las Vegas? No, but this small gambling town on the banks of the Colorado River offers a taste of Vegas minus the glitz, traffic and high costs. Plus, there's much to do here besides gambling. Not only does Laughlin have the Colorado River for boating, swimming, fishing, waterskiing and other sports, but it also has gorgeous Lake Mohave offering much of the same on a grander scale. Golfers will enjoy beautiful courses where reasonable green fees stretch their dollars. For a taste of the Wild West, head to nearby 100-year-old Oatman, where you can catch a mock gunfight and guzzle beer in an old-time saloon. Hiking, anyone? Grapevine Canyon awaits you, famous for the Indian markings - some 800 years old - carved into its boulders. If the slots are calling, you'll find plenty of gaming houses, with water shuttles running between them 24/7. What Laughlin lacks in Vegas glamour, it makes up for in affordability, scenic beauty and aquatic fun.

The town of Lake Louise is nestled in the Canadian Rockies, just 45 minutes east of Banff. Breathtaking mountain scenery and fluffy snow lure skiers and snowboarders to the slopes of the world-class Lake Louise Ski Resort every winter, while in summer this picturesque hamlet overflows with nature lovers are eager to explore unforgettable hiking trails and rock climbing faces. A short drive from downtown is Lake Louise itself, which thrills visitors every summer with its vibrant turquoise waters.

Venture into the unspoiled beauty of 7,000-foot Rocky Mountain vistas, marvel at the contrast of ancient native culture mixed with modern arts, feast on legendary cuisine and relax in rustic sophistication. A visit to Santa Fe, Travel & Leisure's #1 Cultural Getaway, feels a lot like a visit to Europe. The Spanish Colonial charm of this historic destination has been enchanting travelers for over 400 years. And Santa Fe shows no signs of slowing down.

Akumal means "Place of the Turtle" in the Mayan language, and if you snorkel here, you just might see one swimming alongside you. (Don’t touch it, though. That’s prohibited by law.) You’ll definitely see coral and beautiful fish in the clear, sparkling waters. This tourist-friendly little town is about an hour south of Cancun—but it seems light-years away.

Sunny Cancun has much more to offer than its party-town reputation might suggest. Plenty of gorgeous, drama-free family resorts cater to folks who want to experience the tropical Yucatan climate. There are significant Mayan ruins here, such as El Rey and the Yamil Lu’um, a crumbling tower of pale gray stone. Learn more about this ancient civilization at the Museo Maya de Cancun. For a literal taste of Mexico, take a tour of the Museo Sensorial del Tequila.

Pittsburgh has been remade and reimagined. Think 24 miles of riverfront trails, beautiful parks and historic attractions. Home to 90 neighborhoods, the ‘Burgh feels authentic and unpretentious. No visit is complete without a trip to the Strip District or PNC Park, a ride up the Duquesne Incline or a stop at The Andy Warhol Museum. Architecture buffs love Pittsburgh for the amazing downtown buildings. Hollywood producers, do, too—the city has even been called the “Hollywood of the East."

Stretching 126 miles south toward Cuba, the stunning Keys are a perfect escape. Highlights along the way include Key Largo, Islamorada, Marathon, Big Pine Key and the irrepressible Key West. Get up close with an amazing array of fish while snorkeling, diving or fishing in the warm turquoise waters. Creeks, coral and costumed spectacles are other lures along the way. Highway 1 is a spectacular ribbon tying together the islands and atolls of this paradise between the Gulf of Mexico and the Atlantic.

Located on the southeast tip of Florida, Sunny Isles Beach is set on a barrier island surrounded by the Atlantic Ocean and the Intracoastal Waterway. Halfway between Miami and Fort Lauderdale, Sunny Isles Beach is the perfect relaxing escape and includes two miles of fine sand. Visit the landmark fishing pier or enjoy the area's abundant outdoor activities, such as snorkeling.

At the shore in Miami Beach, visitors can swim, surf and jet ski in the warm and crystal-clear Atlantic waters. You can also nap on the white sands, work on a tan or simply watch the beautiful people, especially at South Beach, a favorite of models and celebrities.