Its namesake lake is the major draw for aristocratic Como, where waterside gardens and palatial villas flourish in abundance. Long a playground for the wealthy, this city attracts a mix of tourists and Milanese fashionistas who plan trips across the lake region or to nearby Bellagio.

Bergamo is a northern Italy treasure. Dating from 49 BC, Bergamo has two centers: the Alta (upper) city and the Bassa (lower) city, connected by a funicular and walking trails.  For historic sites, go to Alta for the Piazza Vecchia,the Cattedrale di Bergamo e Battistero, and the Basilica di Santa Maria Maggiore Baptistry,  as well as the quirky mausoleum of Rastelli, the world famous juggler. Bassa is more modern and residential, and boasts Via 20 Settembre - the shopping district.

Nestled at the tip of a promontory jutting into Lake Como, Bellagio boasts unparalleled shoreline and Alpine views. Add in boutique-lined cobblestone streets, Italian villas, and fragrant gardens, and it’s no secret why Bellagio is known as the Pearl of Lake Como.

A gorgeous spot that’s a convenient day trip from Milan, Lake Como recently earned fame as home to Hollywood star George Clooney. But celeb-spotting aside, it’s known for jaw-dropping natural beauty, elegant old villas—and the scenic towns surrounding the lake. Check out Varenna, Bellagio, and Menaggio, which offer great views, historic churches, and water-based activities such as ferries and passenger-only boats.

Varenna is a slow-paced destination—most visitors come here to relax by the lake. But even if "Working on my tan" is the #1 thing on your itinerary, take some time to explore the area. There’s the Castello di Vizio, a medieval fortress surrounded by an olive grove. And you’ll want to view the old, tiered gardens at the Villa Cipressi—they stretch all the way down to the water. Finally, visit the source of the Fiumelatte, a peculiar river—it’s only 250 m long and disappears from October to March.

Perfectly positioned on a lake with the Alps at its back, lucky Lugano has a little bit of everything. Ride a cable car up Monte San Salvatore or Monte Bre for sunny panoramas of lake, rivers, mountains and red-roofed buildings. Explore the town's churches, cathedrals and the expressive and colorful Piazza della Riforma. Sample some slow-cooked Ticinese cuisine, explore the lake on a boat or spend the day at the lido with its Olympic-sized pool.

An elegant resort town on the southern edge of Lake Garda, Sirmione has attracted vacation-goers for centuries. 13th-century Scaligero Castle and the Roman ruins of the Grotte di Catullo are top of the list for most visitors, as is swimming in the lake’s crystal-clear waters.

A magnet for skiers and hikers, these dramatic peaks – including the iconic Matterhorn – range from 3,000 to 15,000 feet and spread across three-fifths of the country. Abundant glaciers, scenic valleys and gorgeous alpine lakes add to the region's visual appeal. The Glacier Express train travels the 7.5-hour route through the Swiss Alps from Zermatt to St. Moritz, passing through fairy-tale villages and over 291 bridges along the way.

Wandering the narrow caruggi alleyways of Genoa is a bit like solving a medieval labyrinth. In the heart of the Italian port city lies Piazza de Ferrari, a main square with a beautiful fountain and a perimeter lined with historic buildings, including the Palace of the Doges the Teatro Carlo Felice, which was destroyed during WWII and subsequently rebuilt. The seaside neighborhood of Boccadasse is vision of pink and yellow buildings that brighten up this lovely fishing village.

Rome wasn't built in a day--and you'll need much more than a day to take in this timeless city. The city is a real-life collage of piazzas, open-air markets, and astonishing historic sites. Toss a coin into the Trevi Fountain, contemplate the Colosseum and the Pantheon, and sample a perfect espresso or gelato before spending an afternoon shopping at the Campo de’Fiori or Via Veneto. Enjoy some of the most memorable meals of your life here, too, from fresh pasta to succulent fried artichokes or a tender oxtail stew.

Lingering over pain au chocolat in a sidewalk café, relaxing after a day of strolling along the Seine and marveling at icons like the Eiffel Tower and the Arc de Triomphe… the perfect Paris experience combines leisure and liveliness with enough time to savor both an exquisite meal and exhibits at the Louvre. Awaken your spirit at Notre Dame, bargain hunt at the Marché aux Puces de Montreuil or for goodies at the Marché Biologique Raspail, then cap it all off with a risqué show at the Moulin Rouge.

Barcelona feels a bit surreal – appropriate, since Salvador Dali spent time here and Spanish Catalan architect Antoni Gaudí designed several of the city’s buildings. Stepping into Gaudí’s Church of the Sacred Family is a bit like falling through the looking glass - a journey that you can continue with a visit to Park Güell. Sip sangria at a sidewalk café in Las Ramblas while watching flamboyant street performers, then create your own moveable feast by floating from tapas bar to tapas bar.

From Shoreditch’s swaggering style to Camden’s punky vibe and chic Portobello Road, London is many worlds in one. The city’s energy means that no two days are the same. Explore royal or historic sites, tick off landmarks from your bucket list, eat and drink in exclusive Michelin-starred restaurants, enjoy a pint in a traditional pub, or get lost down winding cobbled streets and see what you stumble across – when it comes to London, the possibilities are endless.

Dubai is a destination that mixes modern culture with history, adventure with world-class shopping and entertainment. Catch a show at the Dubai Opera, see downtown from atop the Burj Khalifa and spend an afternoon along Dubai Creek exploring the gold, textile and spice souks. If you’re looking for thrills, you can float above the desert dunes in a hot air balloon, climb aboard a high-speed ride at IMG Worlds of Adventure or skydive over the Palm Jumeirah.

Packed with historic landmarks, bustling eateries, and manicured parks, the vibrant city of Lahore exudes culture at every corner. From soaring minarets and colorful facades to street-level stalls selling flavorful Punjabi favorites, the increasingly cosmopolitan city radiates with energy.

Known as the safari capital of Africa, Nairobi is an energetic, modern city that serves as a fascinating introduction to both wildlife and nightlife. Music clubs pulse with life, shops and markets bustle, and a mélange of restaurants will tempt your palate in this former Maasai watering hole. Top sights include the Karen Blixen Museum, Giraffe Centre and the black rhinos of Nairobi National Park. The compact city center is safe to walk in and taxis make other areas accessible.

Walk the Freedom Trail the first time you visit Boston and you'll quickly get a sense of this coastal city's revolutionary spirit and history. But make sure you also explore some of Boston's fine museums (try the Isabella Stewart Gardner, featuring masterpieces displayed in their collector's mansion) and old neighborhoods (like the North End, Boston's Little Italy). You can't claim to have experienced real Boston culture, though, until you've watched a Red Sox game from the bleachers.

Conquering New York in one visit is impossible. Instead, hit the must-sees – the Empire State Building, the Statue of Liberty, Central Park, the Metropolitan Museum of Art – and then explore off the beaten path with visits to The Cloisters or one of the city’s libraries. Indulge in the bohemian shops of the West Village or the fine dining of the Upper West Side. The bustling marketplace inside of Grand Central Station gives you a literal taste of the best the city has to offer.

The windy city is a cornucopia of modern art, fine dining, cutting edge comedy, and die-hard sports fans. Snap a photo of your reflection in the silver Cloud Gate sculpture at Millennium Park before heading to Grant Park to get hit with the refreshing spray of Buckingham Fountain. There are dozens of museums and theater companies in Chicago, so a cultural experience is never hard to find. You’re sure to laugh your head off at the Second City Theater, the professional launch pad of many famous comedians.