Golden palaces, floating markets, majestic porcelain-laid spires…you've never seen a capital city quite like Bangkok. Visit Pratunam or Siam Square for premium shopping, then unwind in the European-style gardens of Dusit. Thon Buri is home to the awesome Wat Arun temple, and over in Phra Nakhon, you’ll find the Wat Pho temple of the Reclining Buddha. Savor mango sticky rice at a food stall before taking in the gilded splendor of the Grand Palace.

The cultural hub of Malaysia, Kuala Lumpur is visually defined by the iconic Petronas Twin Towers, which, at 88 stories high, are the tallest twin buildings in the world and a vision of modern architecture. On the flip side, the Sri Mahamariamman is the oldest Hindu temple in Malaysia, its façade a colorful totem pole of iconography. Shopping at the Central Market is a joyful experience that involves haggling, handicrafts, and happiness.

Dubai is a destination that mixes modern culture with history, adventure with world-class shopping and entertainment. Catch a show at the Dubai Opera, see downtown from atop the Burj Khalifa and spend an afternoon along Dubai Creek exploring the gold, textile and spice souks. If you’re looking for thrills, you can float above the desert dunes in a hot air balloon, climb aboard a high-speed ride at IMG Worlds of Adventure or skydive over the Palm Jumeirah.

Cairo’s an ancient city that also happens to be a modern metropolis—it’s one of the biggest cities in the Middle East and has the traffic and noise issues to prove it. But as long as you’re not looking for solitude, Cairo—the City of the Thousand Minarets—is a splendid place to explore Egyptian history and culture. (Editor's note: Our list was compiled before political unrest prompted many countries to issue travel warnings for Egypt. If you're currently planning a trip to Egypt, please consider the risks and monitor your government's travel alerts.)

Over the centuries, many cultures have added their mark to this prized piece of land. Today, you can experience those influences firsthand by exploring Istanbul’s mahalles (neighborhoods). From the holy sites of Sultanahmet and the 19th-century European elegance of Beyoğlu to the high fashion of Nişantaşı, the vibrant café society of Kadıköy and the football-loving streets of Beşiktaş, it’s easy to see why travelers say that Istanbul isn’t just one city, but many cities within one.

Once a cozy fishing village of only a few thousand people, Bodrum has experienced a renaissance in the last half century that has transformed this once-sleepy community into one of Turkey's most popular vacation hotspots. Writers, intellectuals, artists and musicians have long called this Aegean town home, or second-home, attracting a vibrant cultural scene paralleled only by the town's nightlife. Windswept beaches and glittering waters provide the backdrop to the perfect beach getaway.

Even if you’ve never been to this Cyclades island in the Aegean Sea, you’d still recognize it immediately – candy-colored houses carved into cliffs, sapphire waters, gleaming white buildings topped with half-spheres the color of a stormy sky. Here you’ll find peace as you roam the black sand beaches or the streets of a provincial village like Imerovigli. Beautiful Oia is world famous for its sunsets, which seem tinted with every shade of an artist’s palette.

Once known for smog, traffic and tacky architecture, Athens is a city reformed thanks to fortunes brought by the 2004 Summer Olympics. Spotless parks and streets, an ultra-modern subway, new freeways, an accessible airport and all signs in perfect English make the city easily negotiable. Meriting more than a stopover en route to the islands, sophisticated Athens sites include many pillars of Western history, from the Acropolis to the Temple of Olympian Zeus, as well as treasures in the National Archaeological Museum.

Sitting on the edge of the Baltic, the modern, cosmopolitan city of Helsinki is the World Design Capital for 2012. The beauty of the surrounding nature blends seamlessly with high-tech achievements and contemporary trends. Walking tours of the city center show layers of history, while modern architecture and cutting-edge style stake the city's claim to the future. Choose Helsinki during its endless summer days or get adventurous on crisp, snowy winter nights.