So-called because of the honey-colored stone used to build its villages, the Cotswolds offers visitors the quintessential English experience. The area spans five counties and boasts some of England’s most impressive country houses, castles, and landscapes. Plus, plentiful pubs make it easy to experience authentic English hospitality.

The achingly beautiful Tuscany region of Italy is a touchstone of art, food, and culture. Made up of stunning countryside and distinguished cities, Tuscany is the perfect escape for gastronomes, cognoscenti, and fans of the Italian Renaissance. Visit the stunning Roman Catholic cathedrals and galleries of Florence and Arezzo, or make your way to Pisa to see its hallmark Leaning Tower. A bike tour through olive groves and vineyards is a popular way to literally breathe in the Tuscan atmosphere.

Rome wasn't built in a day--and you'll need much more than a day to take in this timeless city. The city is a real-life collage of piazzas, open-air markets, and astonishing historic sites. Toss a coin into the Trevi Fountain, contemplate the Colosseum and the Pantheon, and sample a perfect espresso or gelato before spending an afternoon shopping at the Campo de’Fiori or Via Veneto. Enjoy some of the most memorable meals of your life here, too, from fresh pasta to succulent fried artichokes or a tender oxtail stew.

A patchwork of vineyards and olive groves, dotted with whitewashed hill towns and sun-bronzed beaches—Italy’s southern heel has no shortage of photogenic landscapes. There are a few surprises, too, including the baroque city of Lecce and the Itria Valley, with its UNESCO-listed trulli houses.

The Berkshires are home to an impressive collection of cultural and historic sights. Get your fill of music, art and theater at Tanglewood, the Boston Symphony's summer home, MASS MoCA, the country's largest contemporary art center, the Norman Rockwell Museum and the Williamstown Theatre Festival. Recreational opportunities also abound, including snowshoeing, snowboarding, skiing, rafting, kayaking, fishing and golf. The Berkshires are an easy drive, just two and a half hours from Boston and New York.

If you’re into eating locally and supporting sustainable agriculture, go to Asheville—and eat, eat, eat. This town of less than 100,000 people has 17 farmers’ markets, and the local restaurant scene is all about taking advantage of the seasonal produce sold there. And don’t miss the area’s microbreweries.