Set on the Gulf of Tigullio between Rapallo and Portofino, the resort/fishing town of Santa Margherita Ligure really couldn’t be in a better neighborhood. Fashionable but much quieter than Portofino, life in Santa Margherita Ligure centers around the lovely palm-laden harbor, where boating and simple sunning are the orders of the day. The town has some good shopping options, lovely cafes and interesting sights like its 16th-century castle and the 17th-century Basilica di Santa Margherita.

A port city of about 30,000 on Italy’s Ligurian Coast, Rapallo lies on the Tigullio Gulf about 15 miles southeast of Genoa. The 16th-century Castello sul Mare (Castle-on-the-Sea) is Rapallo’s most prominent landmark, sitting as it does smack in the harbor. The sixth-century Basilica of Santi Gervasio e Protasio is also worth a visit. For a real treat, take the bus or the funivia (cable car) to the sanctuary of Nostra Signora di Montallegro (Our Lady of Montallegro), which offers stunning views.

One of the most popular resort towns on the Italian Riviera, little Portofino has just over 500 permanent residents. But that all changes on summer days when the sun is shining and the yachting set drops anchor in the harbor to wander about. Boutiques, art galleries, cafes and restaurants line the tiny streets. Diving, hiking and beach-going are popular local pastimes, and there are even some historic sights like the Church of St. Martin (Divo Martino) and the Castello Brown hilltop fortress.

The last of the five villages along the Cinque Terre strip, Monterosso al Mare is the most visited, largely because it has the only sizable sand beach and the biggest hotels. Though it can get very crowded with tourists during the peak summer months, Monterosso is still delightful. The old town area, separated from the more modern resort area by the Aurora tower, is home to the ruins of a medieval castle and San Francesco church, which houses an important Van Dyck painting of the crucifixion.

Often an overnight stop en route to Cinque Terre, La Spezia offers travelers more than just affordable stays. Beyond a working-class port and naval base, there are maritime and archaeological museums, a hilltop castle, and an old town ideal for exploring and sampling Ligurian cuisine.

With a comfortable climate that varies little throughout the year, Sanremo has been a favored tourist destination since the mid-1700s, attracting visitors from all over Europe, including heavy contingents of Russian and British aristocracy. For many, the long stretch of beach is the main attraction, but don’t miss the impressive casino or the hillside medieval section of town called La Pigna. Every year since 1951, the city has hosted Italy’s popular Sanremo Music Festival.

Best known for its incredibly edible contributions to world gastronomy (especially parmigiano cheese and Parma ham), Parma has also been revered by opera lovers (who flock to its Teatro Regio) since the days of Verdi, who was born in nearby Roncole. Parma’s many historic sights include the 11th-century cathedral and its baptistry. Begun in the 12th century, it's considered one of medieval Europe’s most important buildings for its straddling of the Romanesque and Gothic architecture periods.

One of the world’s fashion capitals, Milan offers endless opportunities for chic shopping. Hit the artsy neighborhood of Brera for leather goods and Via Monte Napoleone for exclusive, expensive boutiques. The enchanting mosaics and glass vaults of Galleria Vittorio Emanuele II make shoppers feel like they’re wandering inside a painting. Take break from your spree to gape at the iconic Duomo, then grab tickets to a performance at La Scala. Post-opera, the Navigli district pulses with late-night activity.

Rome wasn't built in a day--and you'll need much more than a day to take in this timeless city. The city is a real-life collage of piazzas, open-air markets, and astonishing historic sites. Toss a coin into the Trevi Fountain, contemplate the Colosseum and the Pantheon, and sample a perfect espresso or gelato before spending an afternoon shopping at the Campo de’Fiori or Via Veneto. Enjoy some of the most memorable meals of your life here, too, from fresh pasta to succulent fried artichokes or a tender oxtail stew.

This city, full of colorful homes, canals and bridges, is one of Europe's most picturesque capitals. Must-sees on any visitor's itinerary include the Anne Frank House, the Van Gogh Museum and the world's only floating flower market. Rent a bike and join thousands of locals navigating Amsterdam's labyrinthine streets, or just take in the sights on foot. For an unusual and memorable alternative to hotels, consider staying in a houseboat.

From Shoreditch’s swaggering style to Camden’s punky vibe and chic Portobello Road, London is many worlds in one. The city’s energy means that no two days are the same. Explore royal or historic sites, tick off landmarks from your bucket list, eat and drink in exclusive Michelin-starred restaurants, enjoy a pint in a traditional pub, or get lost down winding cobbled streets and see what you stumble across – when it comes to London, the possibilities are endless.

You've probably heard that Guinness tastes better in Dublin (fresh from the factory), but what you may not know is that Dublin is a perfect destination for the whole family. No, we're not suggesting you let the kiddies drink a pint. Instead, take them to the Dublin Zoo, to feed the ducks in Stephen's Green or on a picnic in Phoenix Park. Scholars enjoy walking in the literary footsteps of such writers as Yeats and Joyce, while discerning shoppers have their pick of designer boutiques.

Dubai is a destination that mixes modern culture with history, adventure with world-class shopping and entertainment. Catch a show at the Dubai Opera, see downtown from atop the Burj Khalifa and spend an afternoon along Dubai Creek exploring the gold, textile and spice souks. If you’re looking for thrills, you can float above the desert dunes in a hot air balloon, climb aboard a high-speed ride at IMG Worlds of Adventure or skydive over the Palm Jumeirah.

Walk the Freedom Trail the first time you visit Boston and you'll quickly get a sense of this coastal city's revolutionary spirit and history. But make sure you also explore some of Boston's fine museums (try the Isabella Stewart Gardner, featuring masterpieces displayed in their collector's mansion) and old neighborhoods (like the North End, Boston's Little Italy). You can't claim to have experienced real Boston culture, though, until you've watched a Red Sox game from the bleachers.

Detroit is an amazing destination for your next weekend getaway. If exploring is your thing, hop on a bike and meet new friends on the Slow Roll bike tour (you’ll find a unique perspective on the city, and the slow pace is perfect for all skill levels). And while you may not think of Detroit as wine country, the newly opened Detroit Vineyards is one of the country’s largest urban wineries, crafting superior wines right in the heart of the city. Grab your glass and make a toast to the weekend!

Hilly Cincinnati boasts a thriving arts scene, major league sports teams, a world-class zoo and aquarium and a revitalized riverfront with shopping, clubs and restaurants. Located on the Ohio River in southwestern Ohio, Cinci claims more than 4,000 restaurants, and more chili restaurants than any other city in the world. Adrenaline-junkies will want to visit the nearby Kentucky Speedway and Paramount's Kings Island, home of the tallest and fastest wooden roller coaster in the world.

The windy city is a cornucopia of modern art, fine dining, cutting edge comedy, and die-hard sports fans. Snap a photo of your reflection in the silver Cloud Gate sculpture at Millennium Park before heading to Grant Park to get hit with the refreshing spray of Buckingham Fountain. There are dozens of museums and theater companies in Chicago, so a cultural experience is never hard to find. You’re sure to laugh your head off at the Second City Theater, the professional launch pad of many famous comedians.

Gatlinburg, at the heart of Great Smoky Mountains National Park, is an ideal base for a family looking to explore the park's numerous offerings. After you've gone hiking, fishing, rafting or horseback riding, ride an elevator 342 feet to the top of the Gatlinburg Space Needle for stunning views of the Smokies. There's also an amusement center next door with nifty rides and games.