The achingly beautiful Tuscany region of Italy is a touchstone of art, food, and culture. Made up of stunning countryside and distinguished cities, Tuscany is the perfect escape for gastronomes, cognoscenti, and fans of the Italian Renaissance. Visit the stunning Roman Catholic cathedrals and galleries of Florence and Arezzo, or make your way to Pisa to see its hallmark Leaning Tower. A bike tour through olive groves and vineyards is a popular way to literally breathe in the Tuscan atmosphere.

This Tuscan hill town will transport you back to the Middle Ages. Siena's grand cathedral, built in the 1200s, has treasured artworks and marvelous marble floors. The Piazza del Campo, the main town square, is a UNESCO World Heritage Site. It's also home to the Palio, perhaps the most infamous horserace in the world. No goofy hats and mint juleps here—this is a medieval tradition involving bareback riders racing on cobblestones (so as you might imagine, it's quite dangerous). Siena is an easy daytrip by train from Florence, just 43 miles away.

Lucca's array of wonderfully intact historical sites makes it a must-see stop on any Tuscan itinerary. The medieval city walls still stand—you can hike or bike on top of them. Also visit the Duomo di San Martino and the Roman amphitheater.

Perhaps best known these days as the setting for the book and movie “Under the Tuscan Sun,” gorgeous hillside Cortona has a long history dating back even before its time as an important Etruscan center. Top attractions include the Duomo (Cathedral), the small Museo Diocesano across the piazza with its superb art collection, and the fascinating Museo dell'Accademia Etrusca with its assembly of Etruscan and Roman era items. Cortona is also bursting with splendid churches spanning many periods.

While crowds of tourists fill Venice, Florence and Rome, Bologna remains relatively quiet in comparison. This medieval university town is charming, historic and fun to explore… and you'll find Bologna's local cuisine is light-years away from the American deli meat bearing the city's name.

Nearly crossing northern Italy from the Adriatic Sea westward, Emilia-Romagna gets its name from Via Emilia, the Rimini-to-Piacenza ancient Roman road it straddles. With a rich mix of age-old agriculture and modern industry, the region is home to many historic and cultural gems, both in its larger towns like Bologna, Modena and Ravenna, as well as in its many small hilltop villages. Of course, the region’s best offerings also include native culinary wonders like parmigiano cheese and tortellini.

Located near Ravenna, Milano Marittima is a highlight among the tranquil resort towns that line this stretch of the Adriatic Sea. Beyond its beaches, the town’s lush nature park and Casa delle Farfalle (Butterfly House) are some of its star attractions.

The biggest beach resort on the Adriatic Sea, Rimini is a favored Italian seaside holiday destination for Italians themselves. The city offers an impressive nine miles of beaches, though many of these have private access for the scores of hotels facing the shore. The old town, about a 15-minute walk inland, has many interesting sights, including the Arch of Augustus from 27 BC, and Tiberius Bridge from the early 1st century. Rimini also boasts many great restaurants and an energetic nightlife.

Centrally located Umbria's principal cities include Spoleto, Assisi, and Terni. The capital, Perugia, is famed for its chocolate. Take a tour bus or prepare for daredevil Italian drivers if you opt to rent a car. Assisi's Basilica has a host of treasures, including works by Giotto. The town is also home to the crypt of St. Clare, patron saint of television. St. Francis' meditation retreat is in the mountains to the north. Classes at Velia's Cooking Style in Terni make good use of local produce.

Rome wasn't built in a day--and you'll need much more than a day to take in this timeless city. The city is a real-life collage of piazzas, open-air markets, and astonishing historic sites. Toss a coin into the Trevi Fountain, contemplate the Colosseum and the Pantheon, and sample a perfect espresso or gelato before spending an afternoon shopping at the Campo de’Fiori or Via Veneto. Enjoy some of the most memorable meals of your life here, too, from fresh pasta to succulent fried artichokes or a tender oxtail stew.

Lingering over pain au chocolat in a sidewalk café, relaxing after a day of strolling along the Seine and marveling at icons like the Eiffel Tower and the Arc de Triomphe… the perfect Paris experience combines leisure and liveliness with enough time to savor both an exquisite meal and exhibits at the Louvre. Awaken your spirit at Notre Dame, bargain hunt at the Marché aux Puces de Montreuil or for goodies at the Marché Biologique Raspail, then cap it all off with a risqué show at the Moulin Rouge.

From Shoreditch’s swaggering style to Camden’s punky vibe and chic Portobello Road, London is many worlds in one. The city’s energy means that no two days are the same. Explore royal or historic sites, tick off landmarks from your bucket list, eat and drink in exclusive Michelin-starred restaurants, enjoy a pint in a traditional pub, or get lost down winding cobbled streets and see what you stumble across – when it comes to London, the possibilities are endless.

Once known for smog, traffic and tacky architecture, Athens is a city reformed thanks to fortunes brought by the 2004 Summer Olympics. Spotless parks and streets, an ultra-modern subway, new freeways, an accessible airport and all signs in perfect English make the city easily negotiable. Meriting more than a stopover en route to the islands, sophisticated Athens sites include many pillars of Western history, from the Acropolis to the Temple of Olympian Zeus, as well as treasures in the National Archaeological Museum.

The beaches that stretch along Kudasi's Aegean coastline are as diverse in terrain as they are in ambiance. Ladies’ Beach, thusly named because it was once a for women only, is packed with nightclubs, souvenir vendors, restaurants and, of course, sunbathers and swimmers. Grass-lined Gold Beach is well-manicured and peaceful. Ride a horse from there to Long Beach, a playground of beach bars, pool tables and water sports.

Conquering New York in one visit is impossible. Instead, hit the must-sees – the Empire State Building, the Statue of Liberty, Central Park, the Metropolitan Museum of Art – and then explore off the beaten path with visits to The Cloisters or one of the city’s libraries. Indulge in the bohemian shops of the West Village or the fine dining of the Upper West Side. The bustling marketplace inside of Grand Central Station gives you a literal taste of the best the city has to offer.

From the National Mall’s monuments and memorials to vibrant neighborhoods filled with character and charm, DC is a world-class destination featuring breathtaking views, award-winning hotels and hundreds of free things to do. Experience outstanding performing arts at acclaimed theaters, shop in historic Georgetown, hear great live music at legendary venues, enjoy sporting entertainment from six professional franchises and be dazzled by a flourishing dining scene with Michelin-starred restaurants.

Sailing, diving, fishing and soaking up the sun on perfect beaches is what it's all about on the 60 idyllic British Virgin Islands. Largest island Tortola, home to capital Road Town, is a 12 by three mile haven of white sand, lush green mountains, ruins and rum distilleries. Underwater caverns beckon from dramatic Virgin Gorda. Island time rules on laid-back Jost Van Dyke, where swim-up bars serve delicious rum concoctions. Pristine beaches lure visitors to beautiful coral island Anegada.

The festive city of San Juan is the perfect place to experience true Puerto Rican culture. Get to know its roots by exploring the vibrant neighborhood of El Viejo San Juan (Old San Juan), which consists mostly of Spanish colonial buildings. Flesh out your self-guided history lesson with a visit to El Castillo San Felipe del Morro, a 16th century citadel that’s a UNESCO World Heritage Site. Then reward yourself with a cooling dip at Luquillo or Carolina Beach, then a tasty tour of the Bacardi rum plant.