Conquering New York in one visit is impossible. Instead, hit the must-sees – the Empire State Building, the Statue of Liberty, Central Park, the Metropolitan Museum of Art – and then explore off the beaten path with visits to The Cloisters or one of the city’s libraries. Indulge in the bohemian shops of the West Village or the fine dining of the Upper West Side. The bustling marketplace inside of Grand Central Station gives you a literal taste of the best the city has to offer.

Historic Charleston is bursting with Southern charm and hospitality. The city feels a bit like it’s suspended in time, thanks to its antebellum architecture and surrounding plantation landscapes. Take in incredible views of the Battery and the French Quarter as you stroll the Waterfront Park, then become inspired by the cultivated beauty of the gardens at Middleton Place. At night, try a ghost tour for an introduction to the spooky side of the city.

Charming Savannah is the picture of antebellum hospitality, thanks to period architecture and oak-lined streets. It’s tempting to spend your trip just relaxing on vast verandas and sipping mint juleps, but there are plenty of historical sites and museums to explore. Haunting (and possibly haunted) Bonaventure Cemetery is one of the hallmarks of the city, featuring beautiful obelisks, masses of flowers, and ivy-covered crypts. Dine on fresh seafood and creamy grits for a taste of Savannah home cooking.

New Orleans is full of life—but with a laid-back energy that sets it apart from other cities. You’ll wanna soak it all in: impromptu jazz performances up and down Frenchmen Street, the ding of the St. Charles Streetcar, moss-draped trees in the famous Garden District…even its gothic, above-ground cemeteries. (The city’s said to be one of the most haunted in America.) For some, NOLA will always be all about Bourbon Street, but for travelers looking to take it slow, the city’s distinct blend of cultures—including Creole and Cajun—means there’s tons to see, explore, and yes, eat.

At the shore in Miami Beach, visitors can swim, surf and jet ski in the warm and crystal-clear Atlantic waters. You can also nap on the white sands, work on a tan or simply watch the beautiful people, especially at South Beach, a favorite of models and celebrities.

Mayan ruins tower over the sea in Tulum. The formerly walled city was one of the last to be built by the Mayans, and its archaeological sites are incredibly well preserved. Take a break from the beach to visit El Castillo, the Temple of the Frescoes, and the Temple of the Descending God. Explore an underground river under a canopy of stalactites in the sacred caverns of LabnaHa Eco Park, or dive into Cenote Dos Ojos to snorkel inside of caves in the middle of a forest.

Whether you’re a high roller or a low-key lounger, Las Vegas has something to suit your vacation taste. Sample fare from top chefs and cornucopian buffets, try your luck at one of the world’s premier casinos, or take in a spectacular show. Just wandering the Strip is enough to get your heart pumping. Once you’ve had enough of the razzle-dazzle, wave hello to the toothy sea life at the Mandalay Bay Shark Reef, hike Red Rock Canyon, or visit the Neon Museum, where old signs take on new life.

San Diego embodies laid-back California culture, complete with a Boardwalk, surfing communities, and outstanding Mexican food. Breathe in the fresh ocean air at Sunset Cliffs Natural Park, then gobble down a fresh fish taco at a La Jolla seafood joint. The naval aircrafts at the USS Midway Museum will have you standing at attention. A free Sunday concert at the Spreckels Organ Pavilion is the perfect way to unwind after a Saturday night bar-hop in the thumping Gaslamp Quarter.

The festive city of San Juan is the perfect place to experience true Puerto Rican culture. Get to know its roots by exploring the vibrant neighborhood of El Viejo San Juan (Old San Juan), which consists mostly of Spanish colonial buildings. Flesh out your self-guided history lesson with a visit to El Castillo San Felipe del Morro, a 16th century citadel that’s a UNESCO World Heritage Site. Then reward yourself with a cooling dip at Luquillo or Carolina Beach, then a tasty tour of the Bacardi rum plant.

Aruba is the quintessential Caribbean island, all sun and sea and stretches of powdery white sand. Time will slow to a pleasant crawl as you linger over a tropical cocktail or flutter serenely underwater, where only the parrotfish are in a hurry. The pastel façades of Oranjestad landmarks and shops lend an inviting and playful vibe to the capital city. Enjoy the shade of an Eagle Beach divi tree while the crashing waves of turquoise water create a soothing soundtrack just for you.