Myrtle Beach is all at once a spring break destination, golfing destination, retirement community, and family vacation spot. Take in a foot-stomping show at the Carolina Opry, or cheer on your favorite knight at Medieval Times. Mingle with the fishermen of Springmaid Pier, then stop for ice cream along the boardwalk. Shop and dine at one of the area’s many outdoor entertainment complexes, or simply explore the many beaches of the Grand Strand – all with a personality of their own.

Isla Mujeres offers a wide variety of tempting options for beach lovers, and is a relative bargain. Snorkel with tropical fish amid coral reefs, skim the blue waters by kayak or boat, or windsurf along the shores of soft, sandy beaches. On land, you can sunbathe, dine on seafood, dance to Latin rhythms, tour on a moped or belly up to the bar for fresh, delicious drinks.

Sunny Cancun has much more to offer than its party-town reputation might suggest. Plenty of gorgeous, drama-free family resorts cater to folks who want to experience the tropical Yucatan climate. There are significant Mayan ruins here, such as El Rey and the Yamil Lu’um, a crumbling tower of pale gray stone. Learn more about this ancient civilization at the Museo Maya de Cancun. For a literal taste of Mexico, take a tour of the Museo Sensorial del Tequila.

Whether you’re a high roller or a low-key lounger, Las Vegas has something to suit your vacation taste. Sample fare from top chefs and cornucopian buffets, try your luck at one of the world’s premier casinos, or take in a spectacular show. Just wandering the Strip is enough to get your heart pumping. Once you’ve had enough of the razzle-dazzle, wave hello to the toothy sea life at the Mandalay Bay Shark Reef, hike Red Rock Canyon, or visit the Neon Museum, where old signs take on new life.

Strolling, shopping, and sipping tequila along the Malecon boardwalk of Puerto Vallarta is the best way to kick off your vacation. Then hit the cobblestone streets of Old Vallarta to browse the flea market for handmade crafts. The calm, warm waters of the Bay of Banderas make for excellent diving, or you can just watch artists sculpt spectacular creations in the sand. The cluster of fine art galleries in El Centro are perfect spots to hit on a self-guided art tour.

As a well-known destination for both spring breakers and A-list travelers in need of a getaway, Cabo San Lucas has definite vacation cred. The beaches here range in temperament, from the serene waters of the Sea of Cortez and Playa del Amor to the kickin’ waves of Zippers, a surfing paradise. If you care to romp with locals, head to the coves and rock formations of the Cannery beaches. Kids will have a blast communing with the local animals by swimming with dolphins or taking a camel ride through the Desert Park Natural Reserve.

Get the experience of visiting two island colonies in the same 37 square miles. Saint Maarten/Saint Martin's spicy marriage of Caribbean, French and Dutch cultures matches its physical diversity: the island is both urban and untamed, with rain forest-like landscapes, white beaches, and amazing caves and wildlife.

Cartagena, a gorgeous fishing village on Colombia's Caribbean coast, has excellent beaches, a historic old town (that's entirely walkable) and beautiful colonial architecture. It's also one of the safest places in the country, so it's no wonder it's a popular port of call for cruise ships. Need a break from exploring the cobblestone streets? Stop at an outdoor cafe for excellent pastries and people-watching.

The Hawaiian island of Maui is a destination for true nature lovers. The ethereal bamboo forest and churning waterfalls in Haleakala National Park can be explored via the Waimoku Falls Trail. Stretch out on warm, golden sands or hit the surf for an unforgettable windsurfing or snorkeling session. Driving the scenic road to Hana along the island’s northeastern shore will be among the most spectacular journeys of your life. Time stands still at the Hawaiian village of Keanae, definitely worth a visit.