Known as the safari capital of Africa, Nairobi is an energetic, modern city that serves as a fascinating introduction to both wildlife and nightlife. Music clubs pulse with life, shops and markets bustle, and a mélange of restaurants will tempt your palate in this former Maasai watering hole. Top sights include the Karen Blixen Museum, Giraffe Centre and the black rhinos of Nairobi National Park. The compact city center is safe to walk in and taxis make other areas accessible.

The birthplace of the tango is, like the dance itself, captivating, seductive and bustling with excited energy. Atmospheric old neighborhoods are rife with romantic restaurants and thumping nightlife, and Buenos Aires' European heritage is evident in its architecture, boulevards and parks. Cafe Tortoni, the city's oldest bar, will transport you back to 1858, and the spectacular Teatro Colon impresses just as it did in 1908. Latin America's shopping capital offers the promise of premium retail therapy along its grand, wide boulevards.

The shining jewel of Qatar, Doha is a multicultural city, home to most of the country's population as well as expatriate communities from a range of origins. Shopping abounds in the city's plentiful malls, while the Corniche impresses visitors with picturesque architecture and dazzling views of the harbor. Doha boasts myriad cultural facilities, including the futuristic Education City and the National Museum.

A youthful, modern metropolis with a diverse population, Tel Aviv dates back only to 1909. Clubs, bars, a thriving arts community, gay life and beaches attract artists, musicians and young professionals to Tel Aviv's more secular scene. Its UNESCO-designated Bauhaus architecture has won the city the moniker "The White City." Walk, drive or catch cabs between the cultural exhibition pavilions of Haaretz Museum, historic Independence Hall Museum, bustling Carmel Market and Old Jaffa's boardwalk.

Manama, capital of the island nation of Bahrain, is a major financial center with a thriving economy. A surplus of money has decorated the skyline with glass and steel spires, and plans for the tallest tower in the world. Although Bahrain is an Islamic country, alcohol is legal, and Manama has a thriving nightlife, with clubs and bars popular with visitors from all over the world. The narrow rows of stalls at the Bab el-Bahrain souk are famous for their vast array of perfumes, spices, and gold.

Atmospheric backstreets paint a very different picture to first impressions of Abu Dhabi. The often slick and modern capital of the U.A.E. presents a fascinating mixture of tradition and progression. Tracing its rich history back to around 3000 B.C., Abu Dhabi maintains a more distinctly Arabian ambiance than glitzy Dubai. Taxis are a safe, reliable way to get around sites such as The Corniche Park, the White Fort, the Heritage Village, which offers glimpses into Bedouin life, and the Women's Craft Centre.

Dubai is a destination that mixes modern culture with history, adventure with world-class shopping and entertainment. Catch a show at the Dubai Opera, see downtown from atop the Burj Khalifa and spend an afternoon along Dubai Creek exploring the gold, textile and spice souks. If you’re looking for thrills, you can float above the desert dunes in a hot air balloon, climb aboard a high-speed ride at IMG Worlds of Adventure or skydive over the Palm Jumeirah.

Strung below craggy mountains, the Omani capital of Muscat is one of the Middle East’s oldest and most picturesque cities. Between its corniches and modern quarter are Portuguese-built forts, blue-domed mosques, royal palaces, and souks, all heavy with the sense of a lost Arabia.

Tribal Terenife still shows influence from the aboriginal Gaunches people. Visitors clamber to conquer Mount Teide (Spain’s tallest peak) and to stretch out on the sands of Los Gigantes. Squawk hello to the playful parrots of Loro Park, or brave the petrifying drive to beautiful Masca Valley. For a true taste of Terenife, sample fresh farmhouse cheese and local bananas. A piece of delicate calado canario lace makes a special souvenir.

Once known for smog, traffic and tacky architecture, Athens is a city reformed thanks to fortunes brought by the 2004 Summer Olympics. Spotless parks and streets, an ultra-modern subway, new freeways, an accessible airport and all signs in perfect English make the city easily negotiable. Meriting more than a stopover en route to the islands, sophisticated Athens sites include many pillars of Western history, from the Acropolis to the Temple of Olympian Zeus, as well as treasures in the National Archaeological Museum.