The mighty Nile has been providing Egypt with water for millennia. Deserving of its reputation as the world's largest open-air museum, the Nile River Valley contains thousands of monuments at sites such as Luxor and Aswan. Don't miss the city of temples ar Karnak, the dozens of tombs in the Valley of the Kings, the massive rock temples of Abu Simbel or vast and powerful Luxor Temple. Visitors can float by these astounding sites on a felucca boat or cruise ship or catch a train from Cairo.

One of Islam’s most holy cities, Medina, is a sprawl of minarets and shops wrapped around the landmark, the Prophet’s Mosque. Like the rest of central Medina, it’s for Muslims only and is surrounded by plenty of hotels and eateries to welcome the pilgrimage crowd.

Rome wasn't built in a day--and you'll need much more than a day to take in this timeless city. The city is a real-life collage of piazzas, open-air markets, and astonishing historic sites. Toss a coin into the Trevi Fountain, contemplate the Colosseum and the Pantheon, and sample a perfect espresso or gelato before spending an afternoon shopping at the Campo de’Fiori or Via Veneto. Enjoy some of the most memorable meals of your life here, too, from fresh pasta to succulent fried artichokes or a tender oxtail stew.

Dubai is a destination that mixes modern culture with history, adventure with world-class shopping and entertainment. Catch a show at the Dubai Opera, see downtown from atop the Burj Khalifa and spend an afternoon along Dubai Creek exploring the gold, textile and spice souks. If you’re looking for thrills, you can float above the desert dunes in a hot air balloon, climb aboard a high-speed ride at IMG Worlds of Adventure or skydive over the Palm Jumeirah.

Barcelona feels a bit surreal – appropriate, since Salvador Dali spent time here and Spanish Catalan architect Antoni Gaudí designed several of the city’s buildings. Stepping into Gaudí’s Church of the Sacred Family is a bit like falling through the looking glass - a journey that you can continue with a visit to Park Güell. Sip sangria at a sidewalk café in Las Ramblas while watching flamboyant street performers, then create your own moveable feast by floating from tapas bar to tapas bar.

Lingering over pain au chocolat in a sidewalk café, relaxing after a day of strolling along the Seine and marveling at icons like the Eiffel Tower and the Arc de Triomphe… the perfect Paris experience combines leisure and liveliness with enough time to savor both an exquisite meal and exhibits at the Louvre. Awaken your spirit at Notre Dame, bargain hunt at the Marché aux Puces de Montreuil or for goodies at the Marché Biologique Raspail, then cap it all off with a risqué show at the Moulin Rouge.

This city, full of colorful homes, canals and bridges, is one of Europe's most picturesque capitals. Must-sees on any visitor's itinerary include the Anne Frank House, the Van Gogh Museum and the world's only floating flower market. Rent a bike and join thousands of locals navigating Amsterdam's labyrinthine streets, or just take in the sights on foot. For an unusual and memorable alternative to hotels, consider staying in a houseboat.

Known as the safari capital of Africa, Nairobi is an energetic, modern city that serves as a fascinating introduction to both wildlife and nightlife. Music clubs pulse with life, shops and markets bustle, and a mélange of restaurants will tempt your palate in this former Maasai watering hole. Top sights include the Karen Blixen Museum, Giraffe Centre and the black rhinos of Nairobi National Park. The compact city center is safe to walk in and taxis make other areas accessible.

From Shoreditch’s swaggering style to Camden’s punky vibe and chic Portobello Road, London is many worlds in one. The city’s energy means that no two days are the same. Explore royal or historic sites, tick off landmarks from your bucket list, eat and drink in exclusive Michelin-starred restaurants, enjoy a pint in a traditional pub, or get lost down winding cobbled streets and see what you stumble across – when it comes to London, the possibilities are endless.

Golden palaces, floating markets, majestic porcelain-laid spires…you've never seen a capital city quite like Bangkok. Visit Pratunam or Siam Square for premium shopping, then unwind in the European-style gardens of Dusit. Thon Buri is home to the awesome Wat Arun temple, and over in Phra Nakhon, you’ll find the Wat Pho temple of the Reclining Buddha. Savor mango sticky rice at a food stall before taking in the gilded splendor of the Grand Palace.