The historic quarter of Colonia del Sacramento, founded in 1680, evokes old Lisbon with its Portuguese-influenced architecture and winding streets. The area, located in southwestern Uruguay on the Rio de la Plata, was named a UNESCO World Heritage site in 1995. It's an easy day trip by ferry from Buenos Aires, making the beaches a popular Argentinean escape. Major sights include Iglesia Matriz, the country's oldest church, the Municipal Museum and a 17th-century port jutting into the river.

Perched on an island a mere 95 kilometers from the city of São Paulo, this bustling beach town seems a world away from the gargantuan urbanity of the state capital. Among its charms, Guarujá counts 23 separate, stunning beaches, all ripe for swimming, sunning and surfing. Families head to the beach at Enseada; singles, it's all about you at Pernambuco.

The vibrancy of Pereira is due in part to its large population of students, who roam the European-style streets in search of coffee, cheap eats or ways to blow off steam between exams. Explore the nature walks of El Cedral eco-park, then marvel at the exotic creatures you’ll find at both the Zoo Matecaña and the nightclubs of Avenida Simón Bolivar. Pereira is one of the three cities comprising Colombia’s “coffee triangle,” so a perfect cup is never too far away.

Alajuela is all about the pura vida lifestyle—in a way that feels less like a slogan and more like a real way of life. You can feel it everywhere, from the markets to the mountains. Just stop by the Alajuela Central Market to chat with the locals and you'll get a taste of the culture (plus some authentic casado, a Costa Rican classic). Or do a deep dive into Costa Rican history at Juan Santamaría Historical Cultural Museum. Then there's the real draw: nature. Rolling hills, coffee farms, and the looming presence of the Poás Volcano. Hike through a magical cloud forest to get to the crater at Poás Volcano National Park—it will feel like you stepped into another realm. For more magic, visit the La Paz Waterfall Gardens. It's like a fairytale come to life: Waterfalls cascading through the rainforest, butterflies dancing around, and a hummingbird garden that's like something straight out of a dream.

It’s true: parts of Belize are getting touristy. But San Ignacio remains rustic, making it a great base for budget-friendly tropical adventure travel. Canoe on the Macal River, or walk to Mayan ruins at Cahal Pec (just be warned: it's uphill).

Saint Augustine is a luxurious, romantic vacation spot—you’ll find classic hotels and intimate restaurants. Those can be a dime a dozen, though. What sets Saint Augustine apart is its history—it’s the oldest European settlement in the U.S. And nowhere else in the world can you taste the waters of the Fountain of Youth Archeological Park (where Ponce de Leon may have landed). Who knows, if you vacation here, maybe you won’t need that Botox!

The great outdoors is likely to feature prominently in any vacation to Fort Walton Beach. There are two public golf courses in Fort Walton Beach, The Oaks and The Pines, while championship courses such as the one at Regatta Bay are within easy reach. Sea anglers have the opportunity for some fine shore or boat fishing, hunting down the big game fish which populate the waters off the Florida coast. The more adventurous may wish to go surfing - or even take instruction and perform a parachute jump!