The world's southernmost city is located on the Beagle Channel, between the Martial Range and the end of the world. It is a key access point to skiing at Cerro Castor and Glaciar Martial, wildlife adventures with penguins and orcas in the Beagle Channel, and Tierra del Fuego National Park. Of course, it’s also the port of call nearest Antarctica, and a unique destination for kayaking, sailing or having a drink in a warm hotel bar.

A diverse multicultural city of almost 1.3 million, Panama City offers a lot more than an up-close view of the Canal. Shantytowns slink up alongside shiny high-rise condos. The Old City is an atmospheric labyrinth of churches, plazas and palaces. Fifteen miles from downtown Panama City, Soberania National Park is an excellent destination for hiking and birding. For a fascinating look at the canal, take a taxi or local bus to Miraflores Locks Visitor Center and look down on the traffic below.

Philipsburg is the capital of Dutch St. Maarten, a Caribbean island divided into Dutch and French (Saint Martin) sides. Bargain seekers flock to the duty-free and sales-tax-free stores of Philipsburg's mile-long commercial district. Visitors also enjoy the city's art galleries, historic forts, casinos and zoo, as well as Great Bay Beach and its boardwalk. Offshore, on the 12 Metre Challenge, guests can work as part of the crew on one of five boats used in the 1987 America's Cup competition.

Puerto Rico offers the perfect balance of rum-soaked nightlife and tranquil retreat. The Spanish colonial buildings of San Juan set a perfect backdrop for a day of shopping and sightseeing. Hike the massive El Yunque rainforest to see waterfalls, stone towers, and colorful Puerto Rican wildlife. As far as beaches go, it doesn’t get better than the private sands of Isla de Vieques – particularly Mosquito Bay, where by moonlight the water glows blue-green thanks to magical microorganisms.

The festive city of San Juan is the perfect place to experience true Puerto Rican culture. Get to know its roots by exploring the vibrant neighborhood of El Viejo San Juan (Old San Juan), which consists mostly of Spanish colonial buildings. Flesh out your self-guided history lesson with a visit to El Castillo San Felipe del Morro, a 16th century citadel that’s a UNESCO World Heritage Site. Then reward yourself with a cooling dip at Luquillo or Carolina Beach, then a tasty tour of the Bacardi rum plant.

One of the top diving destinations in the world for its bright storybook coral reefs, the island of Cozumel is also home to a variety of natural beaches. Choose a beach with soft white sand for relaxing, or snorkel off a rockier vista. A destination for both adventure and romance, Cozumel has a year-round Caribbean climate, untrammeled jungle and abundant nightlife.

Miami is hot hot hot! And it’s not just the sultry weather. Here, the nightlife is scorching, thanks to a strong Latin influence and spicy salsa culture. Dance the noche away in a nightclub, or indulge in a fancy meal at one of the city’s celebrity-owned restaurants. By day, hit the beach of course, or have yourself a walkabout, taking in Miami’s colorful art deco architecture. Grab a Cuban sandwich in Little Havana, then ride the vintage carousel at Virginia Key Beach Park.

Fort Lauderdale’s canals and charm have earned it the nickname “The Venice of America.” The beaches offer 23 miles of golden sand, lively with the spirited antics of happy vacationers. Sail the blue-green waters on a chartered catamaran, or dive beneath the surface to meet-and-greet the local sea life. Shopping and dining al fresco on Las Olas Boulevard is one of Fort Lauderdale’s greatest pleasures, thanks to adorable shops and prime people-watching.

Cape Canaveral and the neighboring Kennedy Space Center have become synonymous with space travel in the U.S. The first phases of the U.S. space program were conducted at Cape Canaveral Air Force Station, now a historic landmark and home to the Air Force Space and Missile Museum, before operations were moved to Kennedy. In addition to its Space Coast reputation, Canaveral also boasts the historic Cape Canaveral Lighthouse, Merritt Island National Wildlife Refuge and Canaveral National Seashore.

Tampa is a laid-back city with a vibrant arts scene and plenty of opportunities for adventure. Busch Gardens offers thrills for families and risk-averse adrenaline junkies, as does the domed IMAX theater of the Museum of Science and Industry. Spend a day touring Tampa’s many art museums, then cheer on your favorite Tampa Bay team at a home game. Get up close and personal with the majestic lions, tigers, and leopards of the Big Cat Rescue animal sanctuary.