Nipping at the ankles of the Andes, San Carlos is a world-renowned ski destination, set in a landscape offering all the natural wonders of Argentina. Visitors can experience snow, lakes and peaceful beaches, along with vibrant nightclubs and gourmet cuisine. Throughout the year, the area hosts several music festivals, art exhibitions, expositions and conventions.

Incan majesty and Andean baroque exist side-by-side in Cusco's stone streets, epitomized by the Qoriacancha palace and the church of Santo Domingo flanking the Plaza de Armas. In this high-altitude melting pot of Amerindian and mestizo culture, you'll find extraordinary textiles, lively summer festivals and archeological wonders.

Lima, founded by Francisco Pizarro in 1535, is a fascinating city and a treasure trove of history. Explore ancient Incan archeological sites, or stroll through the elegant cathedrals and opulent palaces dating from Spanish colonial times. Downtown Lima is crowded, but you'll enjoy exploring the city's neighborhoods—especially the beachfront areas, which have great shopping and dining and fabulous hotels.

Ten million people call vibrant, passionate, sprawling Bogota home. The energy of this metropolitan heart of Colombia is in part fueled by its hundreds of eclectic and authentic dining hot spots, fantastic wines, and frequent foodie festivals. Ask the locals where they like to eat, then walk off your empanadas and aji with a stroll through the historic district of La Candelaria or during an indulgent shopping adventure on the North Side.

Once infamous for dangerous gangs and drug activity, Medellin has been transformed. It’s now a vibrant destination for travelers seeking a culturally rich vacation. Medellin rises proudly from the belly of the Aburrá Valley, and its natural beauty makes a perfect setting for hiking, zip lining and horseback riding. Travel through lush jungle to Piedra de Penol, then climb the 740 steps to the top—a journey within a journey that rewards you with unforgettable views.

Mayan ruins tower over the sea in Tulum. The formerly walled city was one of the last to be built by the Mayans, and its archaeological sites are incredibly well preserved. Take a break from the beach to visit El Castillo, the Temple of the Frescoes, and the Temple of the Descending God. Explore an underground river under a canopy of stalactites in the sacred caverns of LabnaHa Eco Park, or dive into Cenote Dos Ojos to snorkel inside of caves in the middle of a forest.

Sunny Cancun has much more to offer than its party-town reputation might suggest. Plenty of gorgeous, drama-free family resorts cater to folks who want to experience the tropical Yucatan climate. There are significant Mayan ruins here, such as El Rey and the Yamil Lu’um, a crumbling tower of pale gray stone. Learn more about this ancient civilization at the Museo Maya de Cancun. For a literal taste of Mexico, take a tour of the Museo Sensorial del Tequila.

Hidden gems of Yucatan, such as Tulum, Akumal, Chetumal, Chichen Itza and Merida, offer an authentic taste of Mexico. Akumal and more Caribbean-style Chetumal, near the Belize border, deliver delectable white-sand beaches and great snorkelling. Merida, Chichen Itza and Tulum, with their ancient ruins, offer a passage into the Yucatanâs native history. Nature lovers can jungle trek and swim in subterranean sinkholes filled with crystal-clear water. Bike around the ruins and hop between towns in colectivo vans.

From flat-topped Table Mountain down to the blue waters of Table Bay, Cape Town is simply stunning, but the city doesn't thrive by its looks alone. Proudly multicultural, its flourishing arts, dining, and nightlife scenes are proof of this modern metropolis' creativity and innovative spirit.