Over the centuries, many cultures have added their mark to this prized piece of land. Today, you can experience those influences firsthand by exploring Istanbul’s mahalles (neighborhoods). From the holy sites of Sultanahmet and the 19th-century European elegance of Beyoğlu to the high fashion of Nişantaşı, the vibrant café society of Kadıköy and the football-loving streets of Beşiktaş, it’s easy to see why travelers say that Istanbul isn’t just one city, but many cities within one.

Once a cozy fishing village of only a few thousand people, Bodrum has experienced a renaissance in the last half century that has transformed this once-sleepy community into one of Turkey's most popular vacation hotspots. Writers, intellectuals, artists and musicians have long called this Aegean town home, or second-home, attracting a vibrant cultural scene paralleled only by the town's nightlife. Windswept beaches and glittering waters provide the backdrop to the perfect beach getaway.

Belek, a resort town on the Turkish Riviera, is known for very clean, white-sand beaches surrounded by pine forests. History buffs should plan day trips to the Roman ruins at Perge and the Aspendos amphitheater. Or if you’d prefer a round of golf, bring your clubs—there are excellent courses in the area.

Ibiza: Old Spanish for "party 'til you drop." Perhaps not literally, but this is definitely one of Europe's favorite nightlife playgrounds. Ibiza boasts more than 100 miles of coastline with some 50 beaches, plus plenty of restaurants, bars, and water sports—and clubs, of course. Fit in a little culture and visit Ibiza's UNESCO-designated old town.

Manama, capital of the island nation of Bahrain, is a major financial center with a thriving economy. A surplus of money has decorated the skyline with glass and steel spires, and plans for the tallest tower in the world. Although Bahrain is an Islamic country, alcohol is legal, and Manama has a thriving nightlife, with clubs and bars popular with visitors from all over the world. The narrow rows of stalls at the Bab el-Bahrain souk are famous for their vast array of perfumes, spices, and gold.

The shining jewel of Qatar, Doha is a multicultural city, home to most of the country's population as well as expatriate communities from a range of origins. Shopping abounds in the city's plentiful malls, while the Corniche impresses visitors with picturesque architecture and dazzling views of the harbor. Doha boasts myriad cultural facilities, including the futuristic Education City and the National Museum.

Atmospheric backstreets paint a very different picture to first impressions of Abu Dhabi. The often slick and modern capital of the U.A.E. presents a fascinating mixture of tradition and progression. Tracing its rich history back to around 3000 B.C., Abu Dhabi maintains a more distinctly Arabian ambiance than glitzy Dubai. Taxis are a safe, reliable way to get around sites such as The Corniche Park, the White Fort, the Heritage Village, which offers glimpses into Bedouin life, and the Women's Craft Centre.

Dubai is a destination that mixes modern culture with history, adventure with world-class shopping and entertainment. Catch a show at the Dubai Opera, see downtown from atop the Burj Khalifa and spend an afternoon along Dubai Creek exploring the gold, textile and spice souks. If you’re looking for thrills, you can float above the desert dunes in a hot air balloon, climb aboard a high-speed ride at IMG Worlds of Adventure or skydive over the Palm Jumeirah.

Conquering New York in one visit is impossible. Instead, hit the must-sees – the Empire State Building, the Statue of Liberty, Central Park, the Metropolitan Museum of Art – and then explore off the beaten path with visits to The Cloisters or one of the city’s libraries. Indulge in the bohemian shops of the West Village or the fine dining of the Upper West Side. The bustling marketplace inside of Grand Central Station gives you a literal taste of the best the city has to offer.