Lively Antwerp is a hidden gem. Its medieval streets, Renaissance monuments and vibrant nightlife tend to be overshadowed by its reputation as center of the diamond trade and as the world's fifth-largest port. Biking is a popular choice for getting around this stylish Flemish city. See thousands of Old Masters at the Royal Museum and Rubens House. Experience the bustle of life at the Grote Markt. Marvel at the art and architecture of the still unfinished Cathedral of Our Lady, started in 1351.

Belgium's fourth-largest - and most beautiful - city is home to a quarter of a million people and a flourishing flower export trade. An important port, Ghent's city center is a pedestrian area that is like a museum to early Flemish architecture and a testament to the city's medieval might. Impressive Gothic sites, such as dramatic St. Bavo's Cathedral and the Castle of the Counts, inspire awe. The works of Flemish masters are housed in the distinguished Museum voor Schone Kunst.

What could be more romantic and inspiring than a place that looks like a backdrop for a fairy tale? The medieval overtones of Bruges’ cobblestone streets lead to countless historical, architectural and artistic wonders. Marvel at ornate houses lining intricate canals, and understand why this is a favorite destination for all types of travelers. The whole city emanates an appreciation of the past, a love of the present, and enthusiasm for the future. Don’t miss Hof Bladelin, Groeninge Museum, Church of Our Lady, and Belfry and Market Halls.

Lille is an architectural feast with strong Flemish influences from the Grand Place to the basilica of Notre Dame de la Treille to the quiet streets of row houses and gardens. For art buffs, Lille is home to the Musee d'Art Moderne and the Palais des Beaux Arts. Children will enjoy the Parc de Zoologique. Savvy travelers know that Lille has a fine public transit system, making this historical hotspot a pleasure to visit.

Touching Belgium on its west and just a few miles from Germany to the east, Maastricht is the capital of Holland’s southernmost region, Limburg. A town rich in history and culture, Maastricht boasts two wonderful town squares: Vrijthof, with Sint-Servaas Church, Sint-Jan's Cathedral and many bars, cafes and restaurants; and Markt, home to the town hall and, on Wednesday and Friday mornings, a fantastic vendor market. The city’s Vestigingswerken, or old town fortifications, are another big draw.

Holland's most modern city began as a fishing village in the 13th century. It was developing into an industrial and trading power when German bombers destroyed the city center and harbor in 1940. However, Rotterdam's unique architecture now brings many visitors to bike around this urbane, cosmopolitan city. Old Dutch-style houses can still be found in historic Delfshaven, from where the pilgrims set sail in 1620. Cultural offerings from summer's carnival to classical music give Amsterdam competition.

From Shoreditch’s swaggering style to Camden’s punky vibe and chic Portobello Road, London is many worlds in one. The city’s energy means that no two days are the same. Explore royal or historic sites, tick off landmarks from your bucket list, eat and drink in exclusive Michelin-starred restaurants, enjoy a pint in a traditional pub, or get lost down winding cobbled streets and see what you stumble across – when it comes to London, the possibilities are endless.

Rome wasn't built in a day--and you'll need much more than a day to take in this timeless city. The city is a real-life collage of piazzas, open-air markets, and astonishing historic sites. Toss a coin into the Trevi Fountain, contemplate the Colosseum and the Pantheon, and sample a perfect espresso or gelato before spending an afternoon shopping at the Campo de’Fiori or Via Veneto. Enjoy some of the most memorable meals of your life here, too, from fresh pasta to succulent fried artichokes or a tender oxtail stew.

Once known for smog, traffic and tacky architecture, Athens is a city reformed thanks to fortunes brought by the 2004 Summer Olympics. Spotless parks and streets, an ultra-modern subway, new freeways, an accessible airport and all signs in perfect English make the city easily negotiable. Meriting more than a stopover en route to the islands, sophisticated Athens sites include many pillars of Western history, from the Acropolis to the Temple of Olympian Zeus, as well as treasures in the National Archaeological Museum.

Montreal, c’est si bon! This French-speaking city is considered the cultural capital of Canada, and is a cosmopolitan celebration of Québécois style. A horse-drawn carriage ride around the cobblestone streets and grand buildings of Vieux-Montréal will give you a taste of European flavor. The Basilique Notre-Dame is a confection of stained glass, and the Plateau Mont-Royal district will delight you with its quaint boutiques and cafés. Dig in to a massive plate of poutine to fuel up for a tour of the epic Olympic Park.

Conquering New York in one visit is impossible. Instead, hit the must-sees – the Empire State Building, the Statue of Liberty, Central Park, the Metropolitan Museum of Art – and then explore off the beaten path with visits to The Cloisters or one of the city’s libraries. Indulge in the bohemian shops of the West Village or the fine dining of the Upper West Side. The bustling marketplace inside of Grand Central Station gives you a literal taste of the best the city has to offer.

The windy city is a cornucopia of modern art, fine dining, cutting edge comedy, and die-hard sports fans. Snap a photo of your reflection in the silver Cloud Gate sculpture at Millennium Park before heading to Grant Park to get hit with the refreshing spray of Buckingham Fountain. There are dozens of museums and theater companies in Chicago, so a cultural experience is never hard to find. You’re sure to laugh your head off at the Second City Theater, the professional launch pad of many famous comedians.

Historic Charleston is bursting with Southern charm and hospitality. The city feels a bit like it’s suspended in time, thanks to its antebellum architecture and surrounding plantation landscapes. Take in incredible views of the Battery and the French Quarter as you stroll the Waterfront Park, then become inspired by the cultivated beauty of the gardens at Middleton Place. At night, try a ghost tour for an introduction to the spooky side of the city.

Charming Savannah is the picture of antebellum hospitality, thanks to period architecture and oak-lined streets. It’s tempting to spend your trip just relaxing on vast verandas and sipping mint juleps, but there are plenty of historical sites and museums to explore. Haunting (and possibly haunted) Bonaventure Cemetery is one of the hallmarks of the city, featuring beautiful obelisks, masses of flowers, and ivy-covered crypts. Dine on fresh seafood and creamy grits for a taste of Savannah home cooking.

With live music to be heard all across town, 24/7, 365 days a year, Music City lives up to its name. From honky-tonk bands jamming at Tootsie’s Orchid Lounge to songwriters in the round at the Bluebird Cafe and country music legends rocking the Grand Ole Opry, you never know who you might see. The creative spirit from Nashville's music landscape flows into the area's myriad art galleries, up-and-coming fashion scene, historic landmarks and chef-driven restaurants.

At the shore in Miami Beach, visitors can swim, surf and jet ski in the warm and crystal-clear Atlantic waters. You can also nap on the white sands, work on a tan or simply watch the beautiful people, especially at South Beach, a favorite of models and celebrities.