Berlin is an edgy city, from its fashion to its architecture to its charged political history. The Berlin Wall is a sobering reminder of the hyper-charged postwar atmosphere, and yet the graffiti art that now covers its remnants has become symbolic of social progress. Check out the Weltzeituhr (world time) Clock, topped by a model of the solar system, then turn back time by dining at the historic Zur Letzten Instanz, a 16th century restaurant that was frequented by Napoleon and Beethoven.

Heaven isn’t too far away from Obergurgl. Maybe because, at 6000 feet elevation, it’s the highest church parish in Austria. Or maybe it’s just the skiing. Take a guided tour with an expert mountaineer, explore the wintery dreamscape off-piste or get exclusive “early bird” slope access that ends with oysters and champagne. Or ditch the skis and go for a winter hike or thrilling toboggan ride. Ski huts and rest stops range from rustic to futuristic, all with panoramic views.

With its gondolas, canals, amazing restaurants, and unforgettable romantic ambiance, Venice is definitely a city for one's bucket list. Waterfront palazzos, palaces, and churches make drifting down the Grand Canal feel like cruising through a painting. To really experience Venice you must go to the opera or to a classical music performance, nibble fresh pasta and pastries, and linger in the exhibit halls of an art gallery. Label lovers will drool over the high-end shopping in Piazza San Marco.

One of Puglia’s most picturesque enclaves, Ostuni is known as the White City thanks to its plenitude of white-washed houses. A quick trip from the coast, the city is also celebrated for its labyrinthine streets, cathedral, and ancient defensive walls.

Lingering over pain au chocolat in a sidewalk café, relaxing after a day of strolling along the Seine and marveling at icons like the Eiffel Tower and the Arc de Triomphe… the perfect Paris experience combines leisure and liveliness with enough time to savor both an exquisite meal and exhibits at the Louvre. Awaken your spirit at Notre Dame, bargain hunt at the Marché aux Puces de Montreuil or for goodies at the Marché Biologique Raspail, then cap it all off with a risqué show at the Moulin Rouge.

From Shoreditch’s swaggering style to Camden’s punky vibe and chic Portobello Road, London is many worlds in one. The city’s energy means that no two days are the same. Explore royal or historic sites, tick off landmarks from your bucket list, eat and drink in exclusive Michelin-starred restaurants, enjoy a pint in a traditional pub, or get lost down winding cobbled streets and see what you stumble across – when it comes to London, the possibilities are endless.

Over the centuries, many cultures have added their mark to this prized piece of land. Today, you can experience those influences firsthand by exploring Istanbul’s mahalles (neighborhoods). From the holy sites of Sultanahmet and the 19th-century European elegance of Beyoğlu to the high fashion of Nişantaşı, the vibrant café society of Kadıköy and the football-loving streets of Beşiktaş, it’s easy to see why travelers say that Istanbul isn’t just one city, but many cities within one.

Walk the Freedom Trail the first time you visit Boston and you'll quickly get a sense of this coastal city's revolutionary spirit and history. But make sure you also explore some of Boston's fine museums (try the Isabella Stewart Gardner, featuring masterpieces displayed in their collector's mansion) and old neighborhoods (like the North End, Boston's Little Italy). You can't claim to have experienced real Boston culture, though, until you've watched a Red Sox game from the bleachers.

Conquering New York in one visit is impossible. Instead, hit the must-sees – the Empire State Building, the Statue of Liberty, Central Park, the Metropolitan Museum of Art – and then explore off the beaten path with visits to The Cloisters or one of the city’s libraries. Indulge in the bohemian shops of the West Village or the fine dining of the Upper West Side. The bustling marketplace inside of Grand Central Station gives you a literal taste of the best the city has to offer.