Florence is an art historian’s dream. The Galleria dell'Accademia bursts with works by Michelangelo, who is entombed within the frescoed walls of the Basilica di Santa Croce. Budding photographers can snap pics of the Ponte Vecchio bridge, and serious shoppers can spend a blissful afternoon wandering the shops of Piazza Santo Spirito. Tuscan cuisine pays homage to the region’s bounty. Swipe a hunk of crusty bread across a pool of local olive oil and you’ll be instantly transported to your happiest place.

Lucca's array of wonderfully intact historical sites makes it a must-see stop on any Tuscan itinerary. The medieval city walls still stand—you can hike or bike on top of them. Also visit the Duomo di San Martino and the Roman amphitheater.

Visitors have flocked to Abano Terme to soak in its thermal waters for more than 2,000 years. Situated on the outskirts of Padua, on the edge of the verdant Euganean Hills, the spa town is still popular among wellness seekers today.

So splendid was medieval Verona that its reputation alone inspired Shakespeare to set two plays here (Romeo and Juliet and The Two Gentlemen of Verona). Though its connection to the actual Capulets is tenuous at best, the so-called Juliet's House draws half a million tourists per year, many of them keen on reenacting the balcony scene. Don't miss the Roman amphitheater and the Palazzo Barberi.

The biggest beach resort on the Adriatic Sea, Rimini is a favored Italian seaside holiday destination for Italians themselves. The city offers an impressive nine miles of beaches, though many of these have private access for the scores of hotels facing the shore. The old town, about a 15-minute walk inland, has many interesting sights, including the Arch of Augustus from 27 BC, and Tiberius Bridge from the early 1st century. Rimini also boasts many great restaurants and an energetic nightlife.

Known as Padova in Italian, Padua may be the oldest city in northern Italy, if you believe the claims of its 12th-century BC founding by Trojans. It certainly has history, including its famous university (one of Europe’s oldest, from 1222), the 13th-century Basilica di Sant'Antonio (resting place of St. Anthony), and Scrovegni Chapel, with Giotto’s famed 14th century frescos. The magnificent Prato della Valle, a 950,000-square-foot elliptical square, is thought to be Europe’s second-biggest.

The achingly beautiful Tuscany region of Italy is a touchstone of art, food, and culture. Made up of stunning countryside and distinguished cities, Tuscany is the perfect escape for gastronomes, cognoscenti, and fans of the Italian Renaissance. Visit the stunning Roman Catholic cathedrals and galleries of Florence and Arezzo, or make your way to Pisa to see its hallmark Leaning Tower. A bike tour through olive groves and vineyards is a popular way to literally breathe in the Tuscan atmosphere.

Go ahead and take that photo of yourself with a tilted hand "holding up" the Tower of Pisa. We won't tell; your rep as a sophisticated traveler will remain unblemished. Now that you've gotten that out of the way, climb the tower's 300 steps for a tilted view, or visit the National Museum of San Matteo and the Camposanto cemetery.

San Gimignano, known as the "city of beautiful towers," had 72 towers in its heyday. Now 14 remain, and, rising above Tuscany's Elsa Valley, they make the town look like a medieval dreamscape. Take in the fresco-covered Collegiate Church, the Civic Museum and the views from atop 177-foot Torre Grossa. Daytrippers from Florence tend to fill up the streets during the day, so for a more up-close-and-personal look at the town, spend the night.

Peschiera del Garda is located on the southern end of Lake Garda, in Italy's Veneto region. The town's sixteenth-century island fortress and walls are visible today, a reminder of a time when Austria controlled the region. After exploring Peschiera's history, relax with a glass of Lugana, a local white wine.