Nearly crossing northern Italy from the Adriatic Sea westward, Emilia-Romagna gets its name from Via Emilia, the Rimini-to-Piacenza ancient Roman road it straddles. With a rich mix of age-old agriculture and modern industry, the region is home to many historic and cultural gems, both in its larger towns like Bologna, Modena and Ravenna, as well as in its many small hilltop villages. Of course, the region’s best offerings also include native culinary wonders like parmigiano cheese and tortellini.

Florence is an art historian’s dream. The Galleria dell'Accademia bursts with works by Michelangelo, who is entombed within the frescoed walls of the Basilica di Santa Croce. Budding photographers can snap pics of the Ponte Vecchio bridge, and serious shoppers can spend a blissful afternoon wandering the shops of Piazza Santo Spirito. Tuscan cuisine pays homage to the region’s bounty. Swipe a hunk of crusty bread across a pool of local olive oil and you’ll be instantly transported to your happiest place.

Located near Ravenna, Milano Marittima is a highlight among the tranquil resort towns that line this stretch of the Adriatic Sea. Beyond its beaches, the town’s lush nature park and Casa delle Farfalle (Butterfly House) are some of its star attractions.

Lucca's array of wonderfully intact historical sites makes it a must-see stop on any Tuscan itinerary. The medieval city walls still stand—you can hike or bike on top of them. Also visit the Duomo di San Martino and the Roman amphitheater.

So splendid was medieval Verona that its reputation alone inspired Shakespeare to set two plays here (Romeo and Juliet and The Two Gentlemen of Verona). Though its connection to the actual Capulets is tenuous at best, the so-called Juliet's House draws half a million tourists per year, many of them keen on reenacting the balcony scene. Don't miss the Roman amphitheater and the Palazzo Barberi.

The biggest beach resort on the Adriatic Sea, Rimini is a favored Italian seaside holiday destination for Italians themselves. The city offers an impressive nine miles of beaches, though many of these have private access for the scores of hotels facing the shore. The old town, about a 15-minute walk inland, has many interesting sights, including the Arch of Augustus from 27 BC, and Tiberius Bridge from the early 1st century. Rimini also boasts many great restaurants and an energetic nightlife.

Known as Padova in Italian, Padua may be the oldest city in northern Italy, if you believe the claims of its 12th-century BC founding by Trojans. It certainly has history, including its famous university (one of Europe’s oldest, from 1222), the 13th-century Basilica di Sant'Antonio (resting place of St. Anthony), and Scrovegni Chapel, with Giotto’s famed 14th century frescos. The magnificent Prato della Valle, a 950,000-square-foot elliptical square, is thought to be Europe’s second-biggest.

The achingly beautiful Tuscany region of Italy is a touchstone of art, food, and culture. Made up of stunning countryside and distinguished cities, Tuscany is the perfect escape for gastronomes, cognoscenti, and fans of the Italian Renaissance. Visit the stunning Roman Catholic cathedrals and galleries of Florence and Arezzo, or make your way to Pisa to see its hallmark Leaning Tower. A bike tour through olive groves and vineyards is a popular way to literally breathe in the Tuscan atmosphere.

Riccione is sun-soaked and stylish, an ancient Italian settlement with modern, global flair. Located in the heart of the Eastern Riviera, this coastal destination is the perfect place to sip a cocktail while lounging on golden sands. At night, party people spill from the open-air discos onto the beach, creating a surreal sort of everlasting outdoor party. Zip down a slide at a water park, spin it up on a guided cycling tour, or visit the nearby Misano World Circuit racetrack for an unforgettable getaway.

Rome wasn't built in a day--and you'll need much more than a day to take in this timeless city. The city is a real-life collage of piazzas, open-air markets, and astonishing historic sites. Toss a coin into the Trevi Fountain, contemplate the Colosseum and the Pantheon, and sample a perfect espresso or gelato before spending an afternoon shopping at the Campo de’Fiori or Via Veneto. Enjoy some of the most memorable meals of your life here, too, from fresh pasta to succulent fried artichokes or a tender oxtail stew.

Lingering over pain au chocolat in a sidewalk café, relaxing after a day of strolling along the Seine and marveling at icons like the Eiffel Tower and the Arc de Triomphe… the perfect Paris experience combines leisure and liveliness with enough time to savor both an exquisite meal and exhibits at the Louvre. Awaken your spirit at Notre Dame, bargain hunt at the Marché aux Puces de Montreuil or for goodies at the Marché Biologique Raspail, then cap it all off with a risqué show at the Moulin Rouge.

This city, full of colorful homes, canals and bridges, is one of Europe's most picturesque capitals. Must-sees on any visitor's itinerary include the Anne Frank House, the Van Gogh Museum and the world's only floating flower market. Rent a bike and join thousands of locals navigating Amsterdam's labyrinthine streets, or just take in the sights on foot. For an unusual and memorable alternative to hotels, consider staying in a houseboat.

From Shoreditch’s swaggering style to Camden’s punky vibe and chic Portobello Road, London is many worlds in one. The city’s energy means that no two days are the same. Explore royal or historic sites, tick off landmarks from your bucket list, eat and drink in exclusive Michelin-starred restaurants, enjoy a pint in a traditional pub, or get lost down winding cobbled streets and see what you stumble across – when it comes to London, the possibilities are endless.

Once known for smog, traffic and tacky architecture, Athens is a city reformed thanks to fortunes brought by the 2004 Summer Olympics. Spotless parks and streets, an ultra-modern subway, new freeways, an accessible airport and all signs in perfect English make the city easily negotiable. Meriting more than a stopover en route to the islands, sophisticated Athens sites include many pillars of Western history, from the Acropolis to the Temple of Olympian Zeus, as well as treasures in the National Archaeological Museum.

The valley of Kashmir is as rich with history and political controversy as it is with culture and natural phenomena. Sample exquisitely spiced native cuisines and festive teas, then walk off your meal along the rugged trekking routes to the north. Marvel at the famous houseboats of Srinagar and take a spiritual moment to reflect at one of the many pilgrimage sites and religious shrines that dot the region. Of course, native craftsmanship makes for excellent souvenirs—carpets and textiles are an especial shopping must.

Montreal, c’est si bon! This French-speaking city is considered the cultural capital of Canada, and is a cosmopolitan celebration of Québécois style. A horse-drawn carriage ride around the cobblestone streets and grand buildings of Vieux-Montréal will give you a taste of European flavor. The Basilique Notre-Dame is a confection of stained glass, and the Plateau Mont-Royal district will delight you with its quaint boutiques and cafés. Dig in to a massive plate of poutine to fuel up for a tour of the epic Olympic Park.

Conquering New York in one visit is impossible. Instead, hit the must-sees – the Empire State Building, the Statue of Liberty, Central Park, the Metropolitan Museum of Art – and then explore off the beaten path with visits to The Cloisters or one of the city’s libraries. Indulge in the bohemian shops of the West Village or the fine dining of the Upper West Side. The bustling marketplace inside of Grand Central Station gives you a literal taste of the best the city has to offer.

The windy city is a cornucopia of modern art, fine dining, cutting edge comedy, and die-hard sports fans. Snap a photo of your reflection in the silver Cloud Gate sculpture at Millennium Park before heading to Grant Park to get hit with the refreshing spray of Buckingham Fountain. There are dozens of museums and theater companies in Chicago, so a cultural experience is never hard to find. You’re sure to laugh your head off at the Second City Theater, the professional launch pad of many famous comedians.

Historic Charleston is bursting with Southern charm and hospitality. The city feels a bit like it’s suspended in time, thanks to its antebellum architecture and surrounding plantation landscapes. Take in incredible views of the Battery and the French Quarter as you stroll the Waterfront Park, then become inspired by the cultivated beauty of the gardens at Middleton Place. At night, try a ghost tour for an introduction to the spooky side of the city.