San Pedro is "La Isla Bonita" that Madonna made famous. Now it's a tourist mecca, but still boasts great beaches and plenty of dive shops so you can enjoy the sun, sand, and sea. Plan a side trip to Caye Caulker while you're here; it is less developed and more laid back, and has its own splendid swimming areas.

Ambergris Caye hovers in a vacation sweet spot: just enough amenities to make it exciting, but not so overdeveloped that you’re tripping over flip-flopped tourists. A mangrove swamp is the eye of this white beach island, the largest in Belize, and golf carts are the main form of transportation along the sandy roads. Reef divers drool over the Belize Barrier Reef and the Blue Hole, a 400-feet deep circle of limestone that teems with angelfish, elkhorn coral, cleaner shrimp and stalactites.

Gateway to Belize, Tikal in Guatemala and the numerous Río Bec ruins, Chetumal is the capital of Quintana Roo state. Buses connect major cities, including those in Belize. Rental cars cannot be taken through the Belize border. The busy city's old town boasts a Caribbean feel. The excellent, interactive Museo de la Cultura Maya offers fascinating insights to those planning to follow the dramatic Río Bec ruin route. The vine-strewn ruins are rich in wildlife and give the sense of stumbling onto a Lost World.

It’s true: parts of Belize are getting touristy. But San Ignacio remains rustic, making it a great base for budget-friendly tropical adventure travel. Canoe on the Macal River, or walk to Mayan ruins at Cahal Pec (just be warned: it's uphill).

From the Magic Kingdom to magical spa treatments, Orlando sparkles with the promise of adventure. Spend a day exploring the world-famous Disney theme parks or screaming your head off on a Universal Studios roller coaster. For a less adrenaline-pumping afternoon, enjoy the quiet natural beauty of the Harry P. Leu Gardens or enjoy a seaweed scrub at a luxury day spa. Savor fresh and local ingredients at one of Orlando’s James Beard-nominated restaurants.

Houston hums with an energy and independent spirit all its own. A leading cultural and culinary destination in the South, the city is home to over 11,000 restaurants featuring cuisine from more than 70 countries. The thriving arts scene includes resident opera, ballet, symphony and theater companies. The Museum District houses 19 museums, all within walking distance. Be sure to visit Space Center Houston, where you can visit NASA’s Historic Mission Control at the Johnson Space Center.

From the National Mall’s monuments and memorials to vibrant neighborhoods filled with character and charm, DC is a world-class destination featuring breathtaking views, award-winning hotels and hundreds of free things to do. Experience outstanding performing arts at acclaimed theaters, shop in historic Georgetown, hear great live music at legendary venues, enjoy sporting entertainment from six professional franchises and be dazzled by a flourishing dining scene with Michelin-starred restaurants.

Conquering New York in one visit is impossible. Instead, hit the must-sees – the Empire State Building, the Statue of Liberty, Central Park, the Metropolitan Museum of Art – and then explore off the beaten path with visits to The Cloisters or one of the city’s libraries. Indulge in the bohemian shops of the West Village or the fine dining of the Upper West Side. The bustling marketplace inside of Grand Central Station gives you a literal taste of the best the city has to offer.

Whether you’re a high roller or a low-key lounger, Las Vegas has something to suit your vacation taste. Sample fare from top chefs and cornucopian buffets, try your luck at one of the world’s premier casinos, or take in a spectacular show. Just wandering the Strip is enough to get your heart pumping. Once you’ve had enough of the razzle-dazzle, wave hello to the toothy sea life at the Mandalay Bay Shark Reef, hike Red Rock Canyon, or visit the Neon Museum, where old signs take on new life.

Hollywood beckons to tourists who long for a brush with Tinseltown glamor. Tour movie studios, slip your hands into the famous prints at the TCL Chinese Theatre, or indulge in a celeb sighting at one of LA’s white-hot nightspots. Spot your favorite star while shopping at The Grove, or forget all about the famous eye candy as you take in the iconic artwork at The Getty Center. For a different type of star-gazing, peek through the telescopes at the Griffith Observatory.

South Lake Tahoe is the only destination in the country that combines two strikingly different worlds: The spectacular beauty of a national park, and all the desirable amenities of a world-class resort. Here you can enjoy a full range of exhilarating outdoor activities – from skiing and snowmobiling, snowshoeing, sleigh rides and sledding to hiking, biking, kayaking, boating, fishing, swimming, and golf - alongside the excitement of 24-hour nightclubs, fine dining, gaming and entertainment.

Every neighborhood in San Francisco has its own personality, from the hippie chic of the Upper Haight to the hipster grit of the Mission. The Marina district boasts trendy bistros and postcard-perfect views of the Golden Gate Bridge, while Noe Valley offers quaint and quiet boutiques. Wave hello to the sea lions at Pier 39, and sample local cheese and charcuterie at the Ferry Building. Sit in on a yoga session in Dolores Park or marvel at the Dutch Windmill across from Ocean Beach.