Religious pilgrims have been traveling to Jerusalem for centuries, yet you don’t have to share their zeal in order to appreciate this city’s profound cultural and historical significance. Plan on seeing the major sights, but also leave plenty of time to walk through the streets and simply immerse yourself in the daily life of such an ancient and revered place.

A youthful, modern metropolis with a diverse population, Tel Aviv dates back only to 1909. Clubs, bars, a thriving arts community, gay life and beaches attract artists, musicians and young professionals to Tel Aviv's more secular scene. Its UNESCO-designated Bauhaus architecture has won the city the moniker "The White City." Walk, drive or catch cabs between the cultural exhibition pavilions of Haaretz Museum, historic Independence Hall Museum, bustling Carmel Market and Old Jaffa's boardwalk.

Cairo’s an ancient city that also happens to be a modern metropolis—it’s one of the biggest cities in the Middle East and has the traffic and noise issues to prove it. But as long as you’re not looking for solitude, Cairo—the City of the Thousand Minarets—is a splendid place to explore Egyptian history and culture. (Editor's note: Our list was compiled before political unrest prompted many countries to issue travel warnings for Egypt. If you're currently planning a trip to Egypt, please consider the risks and monitor your government's travel alerts.)

Over the centuries, many cultures have added their mark to this prized piece of land. Today, you can experience those influences firsthand by exploring Istanbul’s mahalles (neighborhoods). From the holy sites of Sultanahmet and the 19th-century European elegance of Beyoğlu to the high fashion of Nişantaşı, the vibrant café society of Kadıköy and the football-loving streets of Beşiktaş, it’s easy to see why travelers say that Istanbul isn’t just one city, but many cities within one.

Manama, capital of the island nation of Bahrain, is a major financial center with a thriving economy. A surplus of money has decorated the skyline with glass and steel spires, and plans for the tallest tower in the world. Although Bahrain is an Islamic country, alcohol is legal, and Manama has a thriving nightlife, with clubs and bars popular with visitors from all over the world. The narrow rows of stalls at the Bab el-Bahrain souk are famous for their vast array of perfumes, spices, and gold.

The shining jewel of Qatar, Doha is a multicultural city, home to most of the country's population as well as expatriate communities from a range of origins. Shopping abounds in the city's plentiful malls, while the Corniche impresses visitors with picturesque architecture and dazzling views of the harbor. Doha boasts myriad cultural facilities, including the futuristic Education City and the National Museum.

Atmospheric backstreets paint a very different picture to first impressions of Abu Dhabi. The often slick and modern capital of the U.A.E. presents a fascinating mixture of tradition and progression. Tracing its rich history back to around 3000 B.C., Abu Dhabi maintains a more distinctly Arabian ambiance than glitzy Dubai. Taxis are a safe, reliable way to get around sites such as The Corniche Park, the White Fort, the Heritage Village, which offers glimpses into Bedouin life, and the Women's Craft Centre.

Dubai is a destination that mixes modern culture with history, adventure with world-class shopping and entertainment. Catch a show at the Dubai Opera, see downtown from atop the Burj Khalifa and spend an afternoon along Dubai Creek exploring the gold, textile and spice souks. If you’re looking for thrills, you can float above the desert dunes in a hot air balloon, climb aboard a high-speed ride at IMG Worlds of Adventure or skydive over the Palm Jumeirah.

Want to make your co-workers insanely jealous? Just casually drop "I’m vacationing in the Maldives this year" into conversation, preferably in the dead of winter. Or better yet, go there without mentioning it to anyone—then send them a "Wish you were here!" postcard.

Golden palaces, floating markets, majestic porcelain-laid spires…you've never seen a capital city quite like Bangkok. Visit Pratunam or Siam Square for premium shopping, then unwind in the European-style gardens of Dusit. Thon Buri is home to the awesome Wat Arun temple, and over in Phra Nakhon, you’ll find the Wat Pho temple of the Reclining Buddha. Savor mango sticky rice at a food stall before taking in the gilded splendor of the Grand Palace.

Thailand’s largest island is an international magnet for beach lovers and serious divers, who enthusiastically submerge themselves in the Andaman Sea. Blue lagoons and salmon sunsets make for a dream-like atmosphere, and indeed, a vacation here can feel a bit surreal. Watersports are the most popular activities, though once you’ve had enough sun there’s still plenty to explore at the island’s aquariums, gardens, and Buddhist temples.