Old school vibe from the very beginning is the only way to describe the Esquilino neighborhood. The Esquilino takes pride in being one of the oldest areas in Rome for its key location on one of the city’s famous seven hills. From an ancient neighborhood to its modern incarnation as a multicultural hub, Esquilino always has something going on—polyglot vendors debate street artists while kids play pick-up basketball games. Look around you: this area isn’t like the historic center. Liberty architecture, large piazzas, and long boulevards mix with archaic arches, secret side alleys, and beautiful churches like Santa Maria Maggiore.

Monti is Rome’s rebel yell. This neighborhood just west of Termini train station mixes grit with fun as it continues to fight for its reputation as a magnet for the artsy, alternative, and hipster. Every season, quirky boutiques and food spots sprout up on its cobblestone streets. The neighborhood supports unique and homegrown businesses that cater to its longtime residents as well as hipsters on the hunt. Hang out at Piazza della Madonna dei Monti anytime after lunch and you'll always find something going on.

With three of Rome’s most beloved piazzas within a five-minute walk of each other, the Navona/Pantheon/Campo area may be the prettiest and most picturesque area of the city. Join the beautiful throngs hanging out in cafes, boutiques, art galleries, and wine bars, or peek at a neighborhood museum or monument. If you want nonstop movida, the streets here are busy with chic bicyclists and Vespa drivers, street vendors, merchants, and locals. There is no rhyme or reason to its winding streets and there's something to see around every corner, so take pleasure in a spontaneous wander.

Trastevere ("beyond the Tiber") is like a faded postcard, a little worn around the edges but still charming. With its wide-open piazzas, meandering streets, weathered Renaissance buildings, and overgrown personality, it's become an irresistible mecca for visitors. Trastevere is an enclave of entertainment - a rotating set of street performers entertains almost every night, and unforgettable eateries and bars pepper its piazzas and side streets. For a trip to the past, visit the southern and western flanks of Trastevere for pockets of yesteryear, less traversed areas with a residual 1960s and 70s Roman vibe.

Thanks to Fellini and La Dolce Vita, the Ludovisi and Via Veneto neighborhood earned its reputation as a posh area where gorgeous Marcellos wooed actresses and models while bored housewives hung out in streetside cafes. The cafes are still there, and so are the cocktails, but the neighborhood is now home to five-star businesses including hotels, banks, law firms, and embassies. The area is also right next to Villa Borghese, a beautiful park for sporting and cultural adventures. If you're looking for tranquility by night, this may be the place: Ludovisi and Veneto tend to shut down after 8pm.