Located at the lower part of Zizkov, Vitkov Hill features the Czech National Monument which features the equestrian sculpture of Jan Zizka (the district bears his name) a national hero and warrior of the proto Protestant Hussite movement who defeated the Papish forces of King Sigismund in 1420 at the Battle of Vitkov Hill.
The building to the rear was formerly a musoleum where the totalitarian communist leaders were interred after death. Their remains have now been removed and the building is now the National Military Museum and a very interesting hour or two can be had there.
If you're staying in Zizkov you can visit the monument by walking up the hill from close to Prokop Square, there are park pathways leading to the top of Vitkov hill or there is a more direct and steeper (not too steep) short-cut.
There are wonderful views of Prague from the hill and the park walkways are pleasant and safe.
If you're traveling in from central Prague you can take the tram numbers 5, 15, 26 to Lipanska or Viktoria Zizkov which are the nearest stops.