Our tour guide was Anna. She was great. She did have a pretty heavy accent, so we had to listen very carefully.
They picked us up at our hotel near Mala Strana and drove us over to Wenceslas Square. We then transferred to a large van (mid-sized bus), which held ~20 people. It was comfortable. It took us a good 3+ hours to get to Cesky Krumlov, primarily due to back traffic. Anna spoke nearly the entire way and then lead us around the city for ~20 minutes, then gave us ~2 hours of free time. We met at the town center at ~3:15pm and Anna took us to the Castle for a tour. We then caught the bus back at 5:30pm and got back at ~8:00pm.
We paid $100 per person but, if I had to do it again, I would have rather just caught a bus from Prague's main station on gone on our own for ~$18 per person round trip. But we're pretty self-sufficent and can read history on our phones. But if you like tour guides, this is a good one.