We stayed at the Corinthia Hotel in Lisbon and were referred by staff to use the bus service from the main Lisbon bus station which was a short walk from our hotel. These are very comfortable, first class coaches. Nothing like a Greyhound bus. We went over a day or two before to buy our tickets. They do not take credit cards so be prepared to pay cash. It was a little less than 2 hours each way by nonstop coach. We spent about 2-3 hours in Fatima and returned that afternoon to Lisbon. If you have a rental car it would be relatively the same actual drive time but this made for a relaxed trip with no worries of directions, etc. enjoy ! dmj