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One option is to drive on Tioga Pass (assuming it is open) with a visit to Mono Lake. Then, drive up Highway 395 with a side trip to view Lake Tahoe.
If Tioga Pass isn't possible, there are some other choices along other High Sierra highways. With four other highways crossing the sierras between Yosemite and Lake Tahoe, there is something for everyone. Note that Highways 120, 108 and 4 are not plowed throughout the winter. Once the weather stops melting the snow off daily, these roads will be closed for the season, which can be as long as 8 months of the year.
Once in Tahoe, stay and play for a while. When heading to Reno as your final stop, you can you can decide which direction to drive around the lake. If you stay on 89 heading north, you will follow the west shore toward Emerald Bay, it's a beautiful drive. In Tahoe City, veer right and continue driving around the lake until you get to the intersection with 267. This will take you north away from the lake past Northstar ski resort and then to the eastern edge of Truckee. If the gliders are operating, you can see them over the meadow. You can pick up 80 going east to Reno. If you choose to go up the Eastern route, follow Highway 50 which takes you through the casino area at stateline and then north, cutting east shortly after Zephyr Cove/Cave Rock.) Head over the pass, connect with 395 at Carson and follow north into Reno.
Note: The original information for this thread came from the following forum thread: http://www.tripadvisor.com/ShowTopic-...