This shop is very San Francisco. Creative, different, inspirational, and has something for everyone. If anyone in your group is interested in arts and crafts, or if  you're looking for some cool gifts, or even if you're just looking for something to interest the kids (they have a great kid's department), these guys seem to have something for everyone. It's owned by a SF family, and seems to pretty well represent the creative scene in SF.

P.S. The cafe next door (Delessio) is phenomenal!