The Cleveland area is easy to navigate around, being based on a grid pattern. Lake Erie is north, and most north-south streets are numbered, starting from Public Square downtown and proceeding east and west. For example, E. 40th Street is just east of downtown, while W. 210th Street is in the west suburbs. Two highways run south from downtown, I-77 which is nearly the east-west dividing line, and I-71, which veers southwest towards Hopkins Airport. Two east-west highways, I-90 close to the lake, and I-480, about 15 miles south, quickly move travelers from one side of town to another - except during morning and evening rush hour, when traffic on all the highways slow down.

Downtown visitors are advised that the Innerbelt Bridge project has caused some changes to traffice patterns and closed highway exits on I-90. Using the free trolleys or the Rapid (trains), run by RTA, are a better choice than driving downtown.