Cherokee has four season weather with hot summers and more mild winters. Summer temperatures average in the 80s and 90s and are very humid, at night the temperature drops down to comfortable 70s and sometimes 60s.

The summer brings in a lot of tourists, hikers, bikers, rafters, kayakers, fisherman, they all flock here during this season and to the national and state parks to get active with whichever of their passion is best fulfilled at the parks. Most of the parks remain open all year round with varying open hours, such as the Great Smoky Mountain National Park and the Appalachian National Scenic Trail.

Visitors should take note of drastic weather changes that take place with altitude change. Reaching the higher peaks of the Smoky Mountains causes anywhere from a 10 to 20 degree drop in degrees. Packing the appropriate clothing is necessary to ensure a comfortable trip in these areas.

Winter starts earlier at the higher altitudes as well, frost begins by September in general. Significant snowfall also occurs in the mountains. Fall however, tends to be the driest period in this region and spring the most unpredictable. Therefore the best time to travel to Cherokee is between late April and early October. The leaves in fall are reason enough for many to plan their trip during that time.