The land where Tunica is now found was originally inhabited by Native Americans known as the Tunica Tribe and hence the name of the city. The Tunica were expert farmers and grew corn and squash among others and hunted animals such as buffalo. The first European to discover the land was a Spanish man by the name Hernando DeSoto in 1540 who met the Tunica here. Unfortunately, the arrival of Europeans also meant the arrival of new diseases to which the Tunica had no immunity and they suffered from sickness. As more Europeans settled into the area of the years the remaining Tunica Indians were pushed out and forced to find new areas.

As more and more people began to settle, Tunica officially became an incorporated town in March of 1888. The land was perfect for harvesting cotton and the industry got the city booming albeit unfortunately with the help of slavery. It was during these years that the Main Street's buildings popped up and that today provide a charming walkway that reminds us of the city's earlier days.

Tunica took a turn for a new direction in the early 1990s when the first Casino went up. The Casino was an instant success and it did not take long for more to be constructed. Today Tunica is known as the "Casino Capital of the South" and visitors flock to gamble and enjoy the charming small town dynamics and great Southern food.