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Before Katrina hit, downtown on Dauphin St. in Mobile has been hopping. There are certain parts of Dauphin closed to traffic on certain nights and police patrol on horseback. An "absolute favorite" among locals is Martini's and upstairs is a small dance club called Club Retro. You can also go out on the New Orleans' like balcony and survey the crowd below. The crowd is well behaved.
There is a police precinct on Dauphin and plenty of supervision. During the day, a nice free trolley service aimed at tourists called MODA runs and sometimes on monthly ArtWalk nights. Look for more good things on the way as downtown owners are now paying a special tax which funds all kinds of great things. Many people meet at the Garage or Bicycle Shop(on Dauphin further West by Wintzell's Oyster House) and walk down Dauphin just past Cathedral Square to the Main bar areas.
Grand Central Station, Boo Radley's, Hayley's and a bar called Soul Kitchen seem popular with the young ones.
Midtown: The Bakery Bar and especially Callaghan's Irish Pub on Marine Street are very good ones. Guido's food is divine. I like Bilotti's as well. The Double Olive is popular too. Do you want to see well to do locals? Go to Ruth's Chris steak house. There are tons of places to eat. Mama's, a late night breakfast place and Picklefish. Port City Brewery for food and beer. Loretta's on Conception, Quatorze and Cafe 615, Wintzell's, Spot of Tea & Three Georges during the day. Hero's Sports Bar and Busaba's Thai food. This is not a comprehensive list just ones I quickly thought up. Here's a good link to try: www.mainstreetmobile.org
** Note: The original information for this thread came from the following forum thread: