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Setúbal is a port and industrial city about 30 miles/48km from Lisbon, south across the Tagus (Tejo) river.
By car from Lisbon Airport or the city you can either cross the Ponte 25 de Abril or the ponte Vasco da Gama and then head south on the motorway/freeway. The drive should take about 40 minutes.
Lisbon Airport to/from bus and train stations
The new metro red line station Aeroporto is now open for operation. The Oriente/Aeroporto red line extension is 3.3 km long and has three new stations, Moscavide, Encarnação and Aeroporto.
You can also to take the Airport bus number 91 or the 44 or the 745 regular city buses to ENTRECAMPOS station. Details at www.carris.pt
If you are travelling by train, there are one or two trains every hour from Lisbon's Roma-Areeiro station stopping on the way at Entrecampos, Sete Rios and Campolide. Note that these trains are operated by a private company called Fertagus. They have their own ticket offices and ticket machines. CP (national railway) tickets are not valid. The train journey takes 56 minutes from Entrecampos.
There are also CP trains at least every hour to and from Barriero, across the river from Lisbon city centre by ferry. The Intercity trains to and from the Algarve also call there. Times and fares on the CP railway website.
Buses - check first which terminal your bus leaves from!
The LISBON CAMPO GRANDE bus terminal is about 1.5 miles/2.5km from the airport. There is no direct bus between the two, although the 31, 83 or 745 run close to Campo Grande they still leave you a 5 minute walk .
The LISBON GARE ORIENTE bus terminal is a similar distance in the opposite direction. Buses 44 or 96 (Aeroshuttle) will take you there in about 10 minutes.
Setúbal is well served by buses, especially if you are intending to go further eg Sesimbra. The bus station is in the centre of town. The local bus operator Transportes Sul do Tejo runs several bus routes to and from Lisbon's Campo Grande and Oriente bus terminals. The 'Rapidas' do the run in 45 - 55 minutes and run early and late, seven days a week and as often as every 5 minutes during weekday rush hours. The same company operates all the local buses in the area. There's a ferry across the river to the popular resort area of Troia operated by Atlantic Ferries. The ferry terminal is 15 minutes walk from the railway station and about 10 minutes walk from the bus station. Ferries run about every 35 minutes and do take motorbikes, cars and camper vans as well as foot passengers.