Mexico City is made up of many different neighbourhoods or colonias, each one having its own distinctive personality and feel.  The areas that will be of most interest to tourists are the Zona Rosa and the Centro Histórico (historic centre).  La Zona Rosa, or Pink Zone, is located south of Paseo de la Reforma. The area is home to many boutiques, restaurants, cafes, galleries, and hotels. It is a pleasant and safe area to walk around and a good place to shop, albeit a bit seedy these days. One of Mexico City's most famous shopping streets, Amberes, is located here.

The heart of the historic centre is the Zócalo and it is where Mexico's federal government offices are located. It is a huge square, often full of lively flea markets and street performers. The Zócalo is surrounded by restaurants, cafes, and shopping streets as well as by many of the city's oldest buildings. The spot where the presidential palace stands on the Zócalo is the same place where the palace of the Aztec king Montezuma once stood.

Other areas of interest to tourists are Polanco, where the city's major hotels, galleries and top designer stores are located, and Roma/Condesa, whose leafy streets have now taken over from the Zona Rosa as the centre for cafe society and bohemian nightlife.