Historic and modern, European and Asian — that's Istanbul. The city at the junction of two continents is home to ancient structures like the Hagia Sophia and the Blue Mosque in the Old City, as well as modern businesses, hotels, restaurants and nightlife in the New City.

It's the East Coast's answer to Las Vegas. Atlantic City's casinos draw tourists by the car- and bus-load, but even if your main objective is to play some blackjack, you'll want to save time for sightseeing.

"When in Rome, do as the Romans." That classic advice leads to a wealth of options: Should you follow Augustus and Caesar, whose Rome is filled with spectacular ancient structures? Or Michelangelo and Da Vinci, whose city invites artistic pilgrimage? Maybe you'll discover the Rome that enchants lovers and sightseers alike? Rome encompasses all this and more.

The second-largest island in Mediterranean after Sicily, Sardinia serves up a lovely blend of sea, sand and history. Thousands of nuraghe (stone buildings) dot the landscape, proof that people have been enjoying the lovely climate here for millennia.