San Francisco was largely defined by the Gold Rush of 1849, but continues to be reinvented every few years. Innovation and entrepreneurship are synonymous with the city and its neighbor, Silicon Valley. The area is most famous for technology, witnessing the dot-com craze and crash, Web 2.0 mania, and the rise of social networking and the smartphone. But San Francisco is still a great place to enjoy all manner of unplugged activities. Walk along the uninterrupted waterfront, through the renovated, foodie-adored Ferry Building, across the iconic Golden Gate Bridge, up the quad-busting inclines to Nob Hill or past the windmills of Golden Gate Park. Mind-expanding cultural attractions exist alongside invigorating outdoor activities. Gaze at the work of Jackson Pollock at the San Francisco Museum of Modern Art in the morning and then head to Muir Woods to peer up at gigantic redwoods in the afternoon. From the hippie haunts of Haight-Ashbury to the colorful Victorian architecture of the predominantly gay Castro District, from Japantown to Chinatown, San Francisco is all about neighborhoods. Each has a distinct look and vibe. You could easily spend a day in each or hop on a streetcar to sample a few.