"When in Rome, do as the Romans." That classic advice leads to a wealth of options: Should you follow Augustus and Caesar, whose Rome is filled with spectacular ancient structures? Or Michelangelo and Da Vinci, whose city invites artistic pilgrimage? Maybe you'll discover the Rome that enchants lovers and sightseers alike? Rome encompasses all this and more.

Culture-seekers will be charmed be La Isla's heritage and history, from Old San Juan's charms to folk art and festivals in the outlying towns.

Mountain views, raucous nightlife and a C-shaped bay with a plethora of beaches make Acapulco a more upscale, yet reasonably priced, escape than its spring-break cousin, Cancun.

Paphos, the capital of western Cyprus, has some serious historical clout. Site of the vast fourth-century BC Tombs of the Kings, set high on a cliff above the sparkling sea, as well as a dramatic Byzantine castle and fine mosaics, it's also known as the birthplace of the goddess Aphrodite.