Best known as the birthplace of St. Francis, Italy's patron saint, Assisi lies amid Umbria's rolling hills. Religious pilgrims have come here for centuries to visit the Basilica of San Francesco (where St. Francis is buried) and the Basilica of Santa Chiara (to see the tomb of St. Clare). Visit the Eremo delle Carceri to see caves where medieval hermits withdrew from the world. (You may find such solitude quite appealing—especially if you're here on a daytrip from Rome!)