"When in Rome, do as the Romans." That classic advice leads to a wealth of options: Should you follow Augustus and Caesar, whose Rome is filled with spectacular ancient structures? Or Michelangelo and Da Vinci, whose city invites artistic pilgrimage? Maybe you'll discover the Rome that enchants lovers and sightseers alike? Rome encompasses all this and more.

Paphos, the capital of western Cyprus, has some serious historical clout. Site of the vast fourth-century BC Tombs of the Kings, set high on a cliff above the sparkling sea, as well as a dramatic Byzantine castle and fine mosaics, it's also known as the birthplace of the goddess Aphrodite.

Corfu refers to both the island and to its main town. Villages of whitewashed houses confetti the sunny isle, two to 15 miles off the Albanian coast.

Historic and modern, European and Asian — that's Istanbul. The city at the junction of two continents is home to ancient structures like the Hagia Sophia and the Blue Mosque in the Old City, as well as modern businesses, hotels, restaurants and nightlife in the New City.