If you are looking for a hotel in the Wertheim area, you should consider staying at the Wertheimer Stuben. Slightly more expensive than some of the hotels in the area but in return you get a very friendly welcome ( Gaby and her staff are wonderful and nothing is too much trouble) a beautiful breakfast buffet and a nice modern well equiped room, lovely bathroom, satelite tv channels, all in all this place is a cut above the average local German hotel. The hotel is located in the middle of Wertheim so everything is within walking distance and has ample parking nearby ( which is free between 6pm - 8.30ish am and not really expensive after that)
Only thing that lets it down slightly for me are the pillows, they are no worse than in other German hotels, but if you are used to a good firm fluffy American/UK style pillow you would be wise to bring your own or use some towels to bulk the pillow out a bit.
Like some similar hotels in the area this hotel does not provide a lunch or evening meal service but there are ample restaurants near and you will be pleasantly surprised by the sumpteous breakfast which you can take until around 2pm I seem to remember. If you are staying elsewhere it would be worth just going to this hotel for the breakfast alone as many locals do over the weekend.