I visited the original 21c in Louisville right after it opened a few years ago. I was very impressed with the hotel, especially the attention to detail and the way they integrated art into the soul of the hotel. The rooms were comfortable and the restaurant was superb. I was a little hesitant to visit their second hotel in the chain in Cincinnati - could they improve on their concept. And the answer is.............YES!
The 21c in Cincinnati is very located in the heart of the city, walking distance to attrractions and best restaurants. It's hip and cool without being overly so - anyone feels comfortable there. the restaurant is loud but the food makes up for the volume.
Cincinnati has been lacking a truly good hotel for years - it's finally arrived!