We live in Austin but every time we visit San Antonio we make a point to come up north (off 1604) to Freetail Bewing Co. It's not a big place but the beers are well-crafted and flavorful, and their food menu is strong too. They have 2 IPSa that are great, try them both to see which you like better! BBQ Chicken Pizza is one of the better ones I've had.
If you're downtown it will be a bit of a trek, but if you're a craft brew fan it will be worth the drive (20-25 minutes from downtown depending on the traffic).
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